Feb 13, 2018

Improving SNP prioritization and pleiotropic architecture estimation by incorporating prior knowledge using graph-GPA

Hang J KimDongjun Chung


Integration of genetic studies for multiple phenotypes is a powerful approach to improving the identification of genetic variants associated with complex traits. Although it has been shown that leveraging shared genetic basis among phenotypes, namely pleiotropy, can increase statistical power to identify risk variants, it remains challenging to effectively integrate genome-wide association study (GWAS) datasets for a large number of phenotypes. We previously developed graph-GPA, a Bayesian hierarchical model that integrates multiple GWAS datasets to boost statistical power for the identification of risk variants and to estimate pleiotropic architecture within a unified framework. Here we propose a novel improvement of graph-GPA which incorporates external knowledge about phenotype-phenotype relationship to guide the estimation of genetic correlation and the association mapping. The application of graph-GPA to GWAS datasets for 12 complex diseases with a prior disease graph obtained from a text mining of biomedical literature illustrates its power to improve the identification of risk genetic variants and to facilitate understanding of genetic relationship among complex diseases. graph-GPA is implemented as an R package 'GGPA', ...Continue Reading

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Mentioned in this Paper

Genome-Wide Association Study
Genetic Pleiotropy
Genetic Studies
Q Fever
Computer Program Package
Single Nucleotide Polymorphism

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