Improving the Clinical Outcome in Stroke Patients Receiving Thrombolytic or Endovascular Treatment in Korea: from the SECRET Study

Journal of Clinical Medicine
Young Dae KimHyo Suk Nam

Abstract

We investigated whether there was an annual change in outcomes in patients who received the thrombolytic therapy or endovascular treatment (EVT) in Korea. This analysis was performed using data from a nationwide multicenter registry for exploring the selection criteria of patients who would benefit from reperfusion therapies in Korea. We compared the annual changes in the modified Rankin scale (mRS) at discharge and after 90 days and the achievement of successful recanalization from 2012 to 2017. We also investigated the determinants of favorable functional outcomes. Among 1230 included patients, the improvement of functional outcome at discharge after reperfusion therapy was noted as the calendar year increased (p < 0.001). The proportion of patients who were discharged to home significantly increased (from 45.6% in 2012 to 58.5% in 2017) (p < 0.001). The successful recanalization rate increased over time from 78.6% in 2012 to 85.1% in 2017 (p = 0.006). Time from door to initiation of reperfusion therapy decreased over the years (p < 0.05). These secular trends of improvements were also observed in 1203 patients with available mRS data at 90 days (p < 0.05). Functional outcome was associated with the calendar year, age, initia...Continue Reading

References

Jul 19, 2003·Stroke; a Journal of Cerebral Circulation·Randall T HigashidaUNKNOWN Technology Assessment Committee of the Society of Interventional Radiology
Jul 3, 2004·Stroke; a Journal of Cerebral Circulation·Larry B GoldsteinRonnie D Horner
Feb 3, 2007·Stroke; a Journal of Cerebral Circulation·Joung-Ho Rha, Jeffrey L Saver
May 13, 2008·Lancet·Geoffrey A DonnanStephen M Davis
Sep 26, 2008·The New England Journal of Medicine·Werner HackeUNKNOWN ECASS Investigators
Jul 24, 2010·Stroke; a Journal of Cerebral Circulation·Ji Hoe HeoMi Sun Oh
Apr 19, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Hye-Yeon ChoiUNKNOWN Korean Stroke Unit Study Collaborators
Mar 15, 2014·Stroke; a Journal of Cerebral Circulation·Atte MeretojaLeonid Churilov
May 3, 2014·Stroke; a Journal of Cerebral Circulation·Walter N KernanUNKNOWN American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and
May 15, 2015·Stroke; a Journal of Cerebral Circulation·Young Dae KimJi Hoe Heo
Oct 14, 2016·Journal of Stroke·Young Dae KimGustavo Saposnik
Jun 9, 2017·Journal of Stroke·Sang-Beom JeonJong S Kim
Mar 11, 2018·BMJ : British Medical Journal·Ivo G H JansenUNKNOWN MR CLEAN Registry investigators
Aug 10, 2018·Cerebrovascular Diseases·Joonsang YooJi Hoe Heo
Sep 11, 2018·Neurointervention·Kwon-Duk Seo, Sang Hyun Suh
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Joonsang YooJi Hoe Heo

❮ Previous
Next ❯

Citations

May 20, 2020·Journal of Clinical Medicine·Joonsang YooSung-Il Sohn
Sep 3, 2020·Journal of Clinical Medicine·Aristeidis H Katsanos
Jan 23, 2021·Journal of Clinical Neurology·Young Dae KimUNKNOWN SMART-EST Study Group
Apr 30, 2021·Stroke; a Journal of Cerebral Circulation·Joonsang YooUNKNOWN SECRET Study Investigators
Jun 10, 2021·Journal of Stroke·Young Dae KimUNKNOWN Thrombus Imaging Study Group and the SECRET Study Group

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT02964052

Software Mentioned

R
SECRET
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.