Improving the identification of dementia with Lewy bodies in the context of an Alzheimer's-type dementia

Alzheimer's Research & Therapy
Alan J ThomasJohannes Attems

Abstract

Dementia due to Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are the two most common neurodegenerative causes of dementia. They commonly occur together, especially in older people, but clinical identification of these diseases in dementia is difficult in such circumstances. We therefore conducted a study using cases with both comprehensive prospective clinical assessments and complete neuropathological examination to determine if it is possible to identify such mixed cases clinically and to determine features which may identify DLB in the presence of AD dementia. At Newcastle Brain Bank we identified subjects who had a clinical diagnosis of dementia and who also had autopsy diagnoses of pure AD, pure DLB, or mixed AD+DLB. All subjects had undergone prospective longitudinal clinical assessments. Mixed AD+DLB patients met neuropathological criteria for both DLB (limbic/neocortical Lewy body disease) and AD (Braak stage V/VI and CERAD B/C). The records of these subjects were carefully reviewed by two specialists in old-age psychiatry blind to autopsy findings to determine baseline and final clinical diagnoses based on these detailed records. The presence of characteristic Lewy body symptoms and other clinical infor...Continue Reading

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Citations

May 16, 2018·Journal of Alzheimer's Disease : JAD·Jennifer RoudilUNKNOWN Brainbank Neuro-CEB Neuropathology Network
Feb 5, 2019·International Journal of Geriatric Psychiatry·Rory DurcanAlan J Thomas
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Jun 13, 2019·Molecular Neurodegeneration·Daniel Twohig, Henrietta M Nielsen
Dec 5, 2020·International Journal of Geriatric Psychiatry·Maria Angeles Prats-SedanoJohn T O'Brien
Feb 14, 2021·Journal of Alzheimer's Disease : JAD·Wim Hendricus QuintThomas Vogels
May 25, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Atri ChatterjeeGing-Yuek Robin Hsiung
Jul 17, 2019·Dementia and Geriatric Cognitive Disorders·George P ParaskevasElisabeth Kapaki
Apr 21, 2020·Dementia and Geriatric Cognitive Disorders Extra·Yasuhiro NagahamaHiroshige Fujishiro

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Minitab
Statistical Package for Social Sciences software SPSS

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