Improving the osteointegration of Ti6Al4V by zeolite MFI coating

Biochemical and Biophysical Research Communications
Yong LiZheng Guo

Abstract

Osteointegration is crucial for success in orthopedic implantation. In recent decades, there have been numerous studies aiming to modify titanium alloys, which are the most widely used materials in orthopedics. Zeolites are solid aluminosilicates whose application in the biomedical field has recently been explored. To this end, MFI zeolites have been developed as titanium alloy coatings and tested in vitro. Nevertheless, the effect of the MFI coating of biomaterials in vivo has not yet been addressed. The aim of the present work is to evaluate the effects of MFI-coated Ti6Al4V implants in vitro and in vivo. After surface modification, the surface was investigated using field emission scanning electron microscopy (FE-SEM) and energy dispersive spectroscopy (EDS). No difference was observed regarding the proliferation of MC3T3-E1 cells on the Ti6Al4V (Ti) and MFI-coated Ti6Al4V (M-Ti) (p > 0.05). However, the attachment of MC3T3-E1 cells was found to be better in the M-Ti group. Additionally, ALP staining and activity assays and quantitative real-time RT-PCR indicated that MC3T3-E1 cells grown on the M-Ti displayed high levels of osteogenic differentiation markers. Moreover, Van-Gieson staining of histological sections demonstrat...Continue Reading

References

Feb 2, 2006·Biomaterials·Tadashi Kokubo, Hiroaki Takadama
Mar 28, 2006·Journal of Biomedical Materials Research. Part a·D P LiuC B Colby
Apr 20, 2006·Colloids and Surfaces. B, Biointerfaces·Kaiyong CaiKlaus D Jandt
Nov 11, 2008·Mini Reviews in Medicinal Chemistry·Marek DanilczukDariusz Pogocki
Mar 3, 2009·Acta Biomaterialia·Milan Mrksich
Jun 23, 2009·Acta Biomaterialia·Eun Jung KimShuvo Roy
Feb 18, 2010·Accounts of Chemical Research·Christopher M LewYushan Yan
Jun 18, 2011·Biochemical and Biophysical Research Communications·Perrine PellegrinoOliver Schäf
Jun 28, 2011·Acta Biomaterialia·Dawit G SeifuKibret Mequanint
Aug 6, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Liang YuLixiong Zhang
Aug 7, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Marios SpanakisDimitrios G Fatouros
Oct 10, 2013·ACS Applied Materials & Interfaces·Neethu NinanYves Grohens
Dec 24, 2013·Colloids and Surfaces. B, Biointerfaces·Neethu NinanYves Grohens
Mar 4, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Christine J FrandsenSungho Jin
May 3, 2014·Advanced Healthcare Materials·Alessandro BertucciLuisa De Cola
May 28, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Jana HavlikovaLucie Bacakova
Jan 23, 2015·Nanotechnology·M KulkarniM Mozetič

❮ Previous
Next ❯

Citations

Jan 7, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Camilla Albeck Neldam, Else Marie Pinholt
Apr 10, 2018·Biomaterials Science·Lucie BacakovaIvan Jirka
Feb 13, 2018·Progress in Biomaterials·A Medina-RamírezG García-Ruiz
Aug 15, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Mahdieh AlipourVahideh Raeisdasteh Hokmabad
Jun 15, 2016·Menopause : the Journal of the North American Menopause Society·Yuan ZangWei Lei
Apr 12, 2019·Clinical Oral Investigations·Francisley Ávila SouzaPaulo Sérgio Perri de Carvalho
Jun 27, 2018··Putu Hadi SetyariniPurnomo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.