Improving the Performances of a "Brick Mass Spectrometer" by Quadrupole Enhanced Dipolar Resonance Ejection from the Linear Ion Trap

Analytical Chemistry
Ting JiangWei Xu

Abstract

Previously, a miniature mass spectrometer driven by a sinusoidal frequency scanning technique, named as Brick mass spectrometer, was developed in our lab ( Jiang et al. Anal. Chem. 2017 , 89 , 5578 ). The frequency scanning technique enabled miniaturized electronics and broader mass range, but it was also limited in reduced mass resolution and sensitivity due to a relatively low operating radio frequency (rf) voltage in comparison with the conventional voltage scanning technique. To improve performances of the Brick mass spectrometer, a quadrupole enhanced dipolar resonance ejection (QE-dipolar resonance ejection) method was proposed in this work. After optimization, mass resolution and sensitivity of the Brick mass spectrometer could be improved by no less than 2 times, and space charge effects within the ion trap could also be reduced. Furthermore, this QE-dipolar resonance ejection method is effective at elevated pressures, which would potentially allow us to further miniaturize the Brick mass spectrometer by operating it at higher pressures. This method is also applicable to any ion trap operated in either frequency scanning mode or voltage scanning mode and operated in either miniaturized instruments or benchtop instruments.

References

Dec 1, 1984·Analytical Chemistry·E B LedfordM L Gross
Jan 1, 1996·Rapid Communications in Mass Spectrometry : RCM·V M Doroshenko, R J Cotter
Jan 13, 2000·Journal of the American Society for Mass Spectrometry·M SudakovT Glebova
Mar 15, 2000·Mass Spectrometry Reviews·R C JohnsonP H Hemberger
Jun 22, 2000·Journal of Mass Spectrometry : JMS·E R Badman, Graham Cooks R
Aug 12, 2000·Analytical Chemistry·E R Badman, R G Cooks
Oct 31, 2000·Analytical Chemistry·E R Badman, R G Cooks
Nov 10, 2000·Journal of the American Society for Mass Spectrometry·B A Collings, D J Douglas
Mar 29, 2002·Rapid Communications in Mass Spectrometry : RCM·Jeremy MoxomJ Michael Ramsey
May 22, 2002·Journal of the American Society for Mass Spectrometry·B A CollingsF A Londry
Jul 30, 2004·Rapid Communications in Mass Spectrometry : RCM·William B WhittenJ Michael Ramsey
Sep 25, 2004·Mass Spectrometry Reviews·Donald J DouglasDunmin Mao
Apr 6, 2006·Rapid Communications in Mass Spectrometry : RCM·Christian JanfeltFrants R Lauritsen
Sep 2, 2006·Analytical Chemistry·Liang GaoZheng Ouyang
Mar 6, 2007·Analytical Chemistry·Daniel E AustinMilton L Lee
Apr 19, 2007·Journal of Mass Spectrometry : JMS·Liang GaoZheng Ouyang
Oct 19, 2007·Rapid Communications in Mass Spectrometry : RCM·Eugene N NikolaevKonstantin S Chingin
Feb 9, 2008·Journal of the American Society for Mass Spectrometry·Xianzhen ZhaoD J Douglas
May 13, 2008·Journal of the American Society for Mass Spectrometry·Daniel E AustinSamuel E Tolley
Aug 18, 2009·Journal of the American Society for Mass Spectrometry·Wei XuZheng Ouyang
Mar 24, 2010·The Analyst·Guangming HuangR Graham Cooks
Jul 20, 2010·Annual Review of Analytical Chemistry·Zheng Ouyang, R Graham Cooks
Feb 1, 2011·JALA : Journal of the Association for Laboratory Automation·Wei XuZheng Ouyang
Mar 27, 2013·Annual Review of Analytical Chemistry·Albert T Lebedev
Jul 1, 1994·Journal of the American Society for Mass Spectrometry·N S ArnoldH L Meuzelaar
May 1, 1991·Journal of the American Society for Mass Spectrometry·J C SchwartzI Jardine
Apr 16, 2016·Journal of the American Society for Mass Spectrometry·Xiaohua ZhangWei Xu
Mar 3, 2017·Analytical Chemistry·Yanbing ZhaiWei Xu
Jun 4, 2017·Journal of the American Society for Mass Spectrometry·Dalton T Snyder, R Graham Cooks
Mar 11, 2018·Journal of the American Society for Mass Spectrometry·Dalton T SnyderR Graham Cooks

❮ Previous
Next ❯

Citations

Apr 17, 2020·The Analyst·Yang TangWei Xu
Dec 4, 2019·Mass Spectrometry Reviews·Przemyslaw MielczarekMarek Smoluch
Apr 14, 2020·Journal of the American Society for Mass Spectrometry·Lucas J SzalwinskiR Graham Cooks

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.