Improving the predictive value of bioaccessibility assays and their use to provide mechanistic insights into bioavailability for toxic metals/metalloids - A research prospectus.

Journal of Toxicology and Environmental Health. Part B, Critical Reviews
Jennifer L GriggsKaren D Bradham

Abstract

Widespread contamination of soil, dust, and food with toxic metal(loid)s pose a significant public health concern. Only a portion of orally ingested metal(loid) contaminants are bioavailable, which is defined as the fraction of ingested metal(loid)s absorbed across the gastrointestinal barrier and into systemic circulation. Bioaccessibility tools are a class of in vitro assays used as a surrogate to estimate risk of oral exposure and bioavailability. Although development and use of bioaccessibility tools have contributed to our understanding of the factors influencing oral bioavailability of metal(loid)s, some of these assays may lack data that support their use in decisions concerning adverse health risks and soil remediation. This review discusses the factors known to influence bioaccessibility of metal(loid) contaminants and evaluates experimental approaches and key findings of SW-846 Test Method 1340, Unified BARGE Method, Simulated Human Intestinal Microbial Ecosystem, Solubility Bioaccessibility Research Consortium assay, In Vitro Gastrointestinal model, TNO-Gastrointestinal Model, and Dutch National Institute for Public Health and the Environment bioaccessibility models which are used to assess oral absolute bioavailabil...Continue Reading

References

Jul 1, 1979·Archives of Environmental Health·D Barltrop, F Meek
Mar 1, 1991·The Science of the Total Environment·J E Fergusson, N D Kim
Dec 23, 1998·Environmental Health Perspectives·M MaddaloniJ Graziano
Sep 26, 2001·Applied and Environmental Microbiology·P MarteauG Corthier
Aug 22, 2002·Environmental Science & Technology·Agnes G OomenJoop H Van Wijnen
Apr 25, 2003·Archives of Environmental Contamination and Toxicology·A G OomenA J A M Sips
Apr 24, 2004·Annals of the New York Academy of Sciences·Joseph P BresslerDesmond Bannona
Jun 20, 2006·Forensic Science International : Synergy·Frank T PetersFrank Musshoff
May 22, 2007·Risk Analysis : an Official Publication of the Society for Risk Analysis·Jianping XueStuart Shalat
Nov 22, 2007·The Journal of Nutrition·Katarzyna KordasRebecca J Stoltzfus
Apr 15, 2010·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Louise MeunierKenneth J Reimer
Jul 7, 2010·Environmental Health Perspectives·Tom Van de WieleKaren Bradham
Jun 28, 2011·The Science of the Total Environment·Joanna WraggTom Van de Wiele
Jul 14, 2011·Environmental Health Perspectives·Karen D BradhamDavid J Thomas
Feb 18, 2012·Metallomics : Integrated Biometal Science·Ebany J Martinez-FinleyMichael Aschner
Feb 28, 2013·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Pradeep AlavaTom R Van de Wiele
Apr 25, 2013·Journal of Toxicology and Environmental Health. Part a·William BrattinLynn Woodbury
Sep 14, 2013·Journal of Toxicology and Environmental Health. Part a·Karen D BradhamDavid J Thomas
Oct 12, 2013·PloS One·Shenghua GuXiao-Lei Wu
Mar 6, 2015·Molecular Biology and Evolution·Carina M SchlebuschKarin Broberg
Oct 21, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M VázquezV Devesa
Nov 21, 2015·Environmental Health Perspectives·Danielle J CarlinWilliam A Suk
Jan 15, 2016·Journal of Agricultural and Food Chemistry·María Jesús ClementeDinoraz Velez
Apr 1, 2016·Journal of Toxicology and Environmental Health. Part a·Gary L DiamondDavid J Thomas
Jun 30, 2016·The Science of the Total Environment·Shakhawat ChowdhuryTahir Husain
Dec 10, 2016·Environmental Science & Technology·Albert L JuhaszEuan Smith
Apr 14, 2017·The Science of the Total Environment·Cameron J OllsonAlbert L Juhasz
Jun 15, 2017·Toxicology and Applied Pharmacology·Liang ChiKun Lu

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Citations

Oct 29, 2021·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Tyler D SowersKaren D Bradham

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