Improving the Structure-Function Relationship in Glaucomatous Visual Fields by Using a Deep Learning-Based Noise Reduction Approach.

Ophthalmology. Glaucoma
Ryo AsaokaTakehiro Yamashita

Abstract

To investigate whether processing visual field (VF) measurements using a variational autoencoder (VAE) improves the structure-function relationship in glaucoma. Cross-sectional study. The training data consisted of 82 433 VF measurements from 16 836 eyes. The testing dataset consisted of 117 eyes of 75 patients with open-angle glaucoma. A VAE model to reconstruct the threshold of VF was developed using the training dataset. OCT and VF (Humphrey Field Analyzer 24-2, Swedish interactive threshold algorithm standard) measurements were carried out for all eyes in the testing dataset. Visual fields in the testing dataset then were reconstructed using the trained VAE. The structure-function relationship between the circumpapillary retinal nerve fiber layer (cpRNFL) thickness and VF sensitivity was investigated in each of twelve 30° segments of the optic disc (3 nasal sectors were merged). Similarly, the structure-function relationship was investigated using the VAE-reconstructed VF. Structure-function relationship. The corrected Akaike information criterion values with threshold were found to be smaller than the threshold reconstructed with the VAE (thresholdVAE) in 9 of 10 sectors. A significant relationship was found between thresh...Continue Reading

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Nov 17, 2012·Investigative Ophthalmology & Visual Science·Ryo AsaokaDavid F Garway-Heath
Jan 21, 2014·Japanese Journal of Ophthalmology·Masanori HangaiNagahisa Yoshimura
Oct 3, 2015·Investigative Ophthalmology & Visual Science·Yukako IshiyamaRyo Asaoka
Oct 18, 2015·American Journal of Ophthalmology·Hae-Young Lopilly ParkChan Kee Park
Dec 10, 2015·Investigative Ophthalmology & Visual Science·Yukako IshiyamaRyo Asaoka
Dec 19, 2017·American Journal of Ophthalmology·Masato MatsuuraRyo Asaoka
Apr 9, 2018·American Journal of Ophthalmology·Masato MatsuuraRyo Asaoka

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Citations

Jul 16, 2021·The British Journal of Ophthalmology·Kenichi NakaharaHiroshi Murata

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