Improving the translational potential of rodent models to study the behavioral and pathophysiological effects of repetitive mild traumatic brain injury

Journal of Neurophysiology
Megan E Huibregtse

Abstract

Chronic traumatic encephalopathy (CTE) is thought to be caused by repetitive head impacts. Consequently, there is a need to develop rodent models to better understand the behavioral and pathophysiological changes of repetitive mild traumatic brain injury (rmTBI) and to determine the link between rmTBI and CTE. This Neuro Forum article reviews recent rodent rmTBI models, comparing the impact methods and outcome measures in terms of translational potential.

References

Nov 29, 2013·Journal of Neurotrauma·Richelle MychasiukMichael J Esser
May 19, 2017·The Journal of Trauma and Acute Care Surgery·Gretchen M ThomsenEric J Ley
Jul 26, 2017·JAMA : the Journal of the American Medical Association·Jesse MezAnn C McKee

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Citations

May 6, 2020·Therapeutic Hypothermia and Temperature Management·Joseph WassermanW Dalton Dietrich
Feb 3, 2021·Fundamental & Clinical Pharmacology·Dominique LerouetValérie C Besson

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Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.