Improving theranostics in pancreatic cancer

Journal of Surgical Oncology
Jeremy KingJohn Williams

Abstract

Pancreatic cancer is the fourth most deadly cancer in the United States, and is expected to be the second most deadly by 2030. The major difficulty in treating pancreatic cancer is the late onset of symptoms. Generally, patients show metastatic disease by the time of diagnosis, with a survival rate of 5% beyond 5 years. In patients without metastatic disease, surgical resection increases 5 year survival rate to 25%. The remaining 75% succumb to undetected metastases. Clearly, improvements to both detection, surgical intervention, and therapeutic strategies will be needed to improve patient outcome in pancreatic cancer. Recent literature has been surveyed and atomic models of new therapeutic approaches were generated. Here, we focus on the recent progress employing monoclonal antibodies (mAbs) to target pancreatic cancer associated markers, and more specifically on recent chemical and protein engineering efforts to improve the homogeneity, stability, and administration of mAbs to precisely deliver imaging agents and cytotoxins to sites of disease.

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Citations

Nov 28, 2019·Journal of Cellular Biochemistry·Zhenyong Wang
Apr 23, 2021·Genes & Cancer·Meena Kishore SakharkarJian Yang
Feb 5, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Miao LiWeibo Cai
Mar 24, 2020·Molecular Pharmaceutics·Carolina A FerreiraWeibo Cai

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