Improving Tumor Treating Fields Treatment Efficacy in Patients With Glioblastoma Using Personalized Array Layouts

International Journal of Radiation Oncology, Biology, Physics
Cornelia WengerPedro C Miranda

Abstract

To investigate tumors of different size, shape, and location and the effect of varying transducer layouts on Tumor Treating Fields (TTFields) distribution in an anisotropic model. A realistic human head model was generated from MR images of 1 healthy subject. Four different virtual tumors were placed at separate locations. The transducer arrays were modeled to mimic the TTFields-delivering commercial device. For each tumor location, varying array layouts were tested. The finite element method was used to calculate the electric field distribution, taking into account tissue heterogeneity and anisotropy. In all tumors, the average electric field induced by either of the 2 perpendicular array layouts exceeded the 1-V/cm therapeutic threshold value for TTFields effectiveness. Field strength within a tumor did not correlate with its size and shape but was higher in more superficial tumors. Additionally, it always increased when the array was adapted to the tumor's location. Compared with a default layout, the largest increase in field strength was 184%, and the highest average field strength induced in a tumor was 2.21 V/cm. These results suggest that adapting array layouts to specific tumor locations can significantly increase fiel...Continue Reading

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Citations

Aug 2, 2016·International Journal of Radiation Oncology, Biology, Physics·Eric E KleinYan Yu
Jul 12, 2018·IEEE Reviews in Biomedical Engineering·Cornelia WengerAnders R Korshoej
Aug 1, 2020·Current Treatment Options in Oncology·Ashley P GhiaseddinDavid D Tran
May 10, 2018·Scientific Reports·Andrea R Di SebastianoMatthew O Hebb
Jan 4, 2021·Journal of Applied Clinical Medical Physics·Youness NourNika Guberina
Jul 3, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shiyu LiuXin Jiang
Aug 20, 2021·Advances in Radiation Oncology·Edwin LokEric T Wong
Sep 4, 2021·Bioelectricity·Jade A PhillipsMustafa B A Djamgoz
Aug 21, 2020·Computer Methods and Programs in Biomedicine·Nichal Gentilal, Pedro Cavaleiro Miranda

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