Improving vaccine potency through intercellular spreading and enhanced MHC class I presentation of antigen

The Journal of Immunology : Official Journal of the American Association of Immunologists
C-F HungT C Wu

Abstract

The potency of naked DNA vaccines is limited by their inability to amplify and spread in vivo. VP22, a HSV-1 protein, has demonstrated the remarkable property of intercellular transport and may thus provide a unique approach for enhancing vaccine potency. Therefore, we created a novel fusion of VP22 with a model Ag, human papillomavirus type 16 E7, in a DNA vaccine that generated enhanced spreading and MHC class I presentation of AG: These properties led to a dramatic increase in the number of E7-specific CD8(+) T cell precursors in vaccinated mice (around 50-fold) and converted a less effective DNA vaccine into one with significant potency against E7-expressing tumors. In comparison, nonspreading VP22(1-267) mutants failed to enhance vaccine potency. Our data indicated that the potency of DNA vaccines may be dramatically improved through intercellular spreading and enhanced MHC class I presentation of Ag.

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Citations

Aug 9, 2003·Expert Review of Vaccines·Margaret A Stanley
Jan 9, 2004·Expert Review of Vaccines·Richard Roden, T-C Wu
Apr 14, 2004·Critical Reviews in Clinical Laboratory Sciences·Sharmila ManojSylvia van Drunen Littel-van den Hurk
Jun 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sanjay GargJoshy Jacob
Jul 6, 2004·Immunological Reviews·Jens A LeifertJ Lindsay Whitton
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Miguel-Angel PeralesMarcel R M van den Brink
Apr 9, 2008·Journal of Biomedical Science·Annie A WuSara I Pai
Mar 5, 2010·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Jun-Han SuT-C Wu
Dec 18, 2009·The Journal of General Virology·Shaunivan L LabiukSylvia van Drunen Littel-van den Hurk
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Tae Heung KangTae Woo Kim
Jun 29, 2013·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Yvonne DrechslerEllen W Collisson
Feb 15, 2019·Current Drug Delivery·Jieru YangMariusz Skwarczynskia
May 11, 2002·Nature Reviews. Immunology·Drew M Pardoll
Jul 30, 2005·Expert Opinion on Biological Therapy·Volker Schirrmacher
Jul 13, 2006·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Katie L Green, Kevin Gaston
Jan 13, 2010·Immunologic Research·Ken LinT-C Wu
Mar 28, 2008·Immunological Reviews·Chien-Fu HungRichard Roden
Nov 1, 2008·Animal : an International Journal of Animal Bioscience·Li HanL G Yang
Sep 3, 2009·Expert Review of Vaccines·Archana MonieT-C Wu
Mar 1, 2016·Chemical Science·Waleed M HusseinMariusz Skwarczynski
Jan 15, 2005·Journal of Virology·Chunfu ZhengSylvia van Drunen Littel-van den Hurk
Mar 6, 2004·DNA and Cell Biology·Toshi NagataYukio Koide
Mar 21, 2008·Expert Opinion on Biological Therapy·Chien-Fu HungT-C Wu
Oct 8, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Kalpana DevarajT-C Wu
Apr 6, 2007·Expert Review of Vaccines·Shaw-Wei D TsenT-C Wu
Apr 24, 2014·Therapeutic Advances in Vaccines·Emeline Ragonnaud, Peter Holst
Jan 11, 2018·Human Gene Therapy·Max A ChengT-C Wu
Oct 5, 2019·Expert Opinion on Drug Delivery·Kimia KardaniAzam Bolhassani
Dec 31, 2020·Viruses·Christos DogrammatzisMaria Kalamvoki

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