Impulse Control Disorder in Parkinson's Disease: A Meta-Analysis of Cognitive, Affective, and Motivational Correlates

Frontiers in Neurology
Alice MartiniStefano Tamburin

Abstract

Background: In Parkinson's disease (PD), impulse control disorders (ICDs) develop as side-effect of dopaminergic replacement therapy (DRT). Cognitive, affective, and motivational correlates of ICD in medicated PD patients are debated. Here, we systematically reviewed and meta-analyzed the evidence for an association between ICD in PD and cognitive, affective, and motivational abnormalities. Methods: A systematic review and meta-analysis was performed on PubMed, Science Direct, ISI Web of Science, Cochrane, EBSCO for studies published between 1-1-2000 and 8-3-2017 comparing cognitive, affective, and motivational measures in PD patients with ICD (ICD+) vs. those without ICD (ICD-). Exclusion criteria were conditions other than PD, substance and/or alcohol abuse, dementia, drug naïve patients, cognition assessed by self-report tools. Standardized mean difference (SMD) was used, and random-effect model applied. Results: 10,200 studies were screened (title, abstract), 79 full-texts were assessed, and 25 were included (ICD+: 625 patients; ICD-: 938). Compared to ICD-, ICD+ showed worse performance reward-related decision-making (0.42 [0.02, 0.82], p = 0.04) and set-shifting tasks (SMD = -0.49 [95% CI -0.78, -0.21], p = 0.0008). ICD i...Continue Reading

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Citations

Feb 5, 2019·Eating and Weight Disorders : EWD·Ingrid de ChazeronPierre Michel Llorca
Oct 20, 2019·Journal of Neurology·Aleksander H ErgaKenn Freddy Pedersen
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Oct 6, 2020·Frontiers in Neuroscience·Chiara ZucchellaStefano Tamburin
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Jan 25, 2021·Parkinsonism & Related Disorders·Alice MartiniStefano Tamburin
Sep 22, 2019·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Charlotte SpayPhilippe Boulinguez

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Software Mentioned

ISI Web of Science
SPSS
Rayyan

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