Impulsivity in Parkinson's Disease Is Associated With Alterations in Affective and Sensorimotor Striatal Networks

Frontiers in Neurology
Marit F L RuitenbergRachael D Seidler

Abstract

A subset of patients with Parkinson's disease (PD) experiences problems with impulse control, characterized by a loss of voluntary control over impulses, drives, or temptations regarding excessive hedonic behavior. The present study aimed to better understand the neural basis of such impulse control disorders (ICDs) in PD. We collected resting-state functional connectivity and structural MRI data from 21 PD patients with ICDs and 30 patients without such disorders. To assess impulsivity, all patients completed the Barratt Impulsiveness Scale and performed an information-gathering task. MRI results demonstrated substantial differences in neural characteristics between PD patients with and without ICDs. Results showed that impulsivity was linked to alterations in affective basal ganglia circuitries. Specifically, reduced frontal-striatal connectivity and GPe volume were associated with more impulsivity. We suggest that these changes affect decision making and result in a preference for risky or inappropriate actions. Results further showed that impulsivity was linked to alterations in sensorimotor striatal networks. Enhanced connectivity within this network and larger putamen volume were associated with more impulsivity. We propo...Continue Reading

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Citations

Aug 20, 2019·Journal of Neuropsychology·Viola Angela IzzoCaterina Primi
Oct 11, 2019·BMJ : British Medical Journal·Anna Lene SeidlerLisa Askie
May 7, 2019·Frontiers in Neurology·Emilia M Gatto, Victoria Aldinio
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Dec 29, 2020·Journal of Parkinson's Disease·Michael F SalvatoreVicki A Nejtek
Mar 17, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Matthias KirschnerAlain Dagher
Apr 2, 2021·Frontiers in Neuroscience·Andrea AugustineVaishnav Krishnan
Apr 28, 2021·Neuroscience and Biobehavioral Reviews·M F L RuitenbergE L Abrahamse
Apr 6, 2021·Brain Connectivity·David Mata-MarínIgnacio Obeso

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Methods Mentioned

BETA
genotyping

Software Mentioned

CONN
SPM12
SPM
FSL
Matlab
ART toolbox
ANTs
Brain Extraction Tool
N4ITK
FMRIB

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