Impurity analysis of pharmaceuticals using capillary electromigration methods

Electrophoresis
Abolghasem Jouyban, Ernst Kenndler

Abstract

This review deals with the determination of impurities in pharmaceuticals by electromigration methods in the capillary format. These separation methods are either based on the different effective mobility of the charged analytes (as in zone electrophoresis and isotachophoresis) or include hybrid methods such as micellar electrokinetic chromatography, microemulsion electrokinetic chromatography and electrochromatography. The pharmaceutically active compounds under consideration belong to chemotherapeutic agents, central nervous system drugs, histamine receptor drugs, cardiovascular drugs, anticancer drugs, anti-inflammatory drugs and some other drugs. The review discusses about 150 publications from the period between 1980 and 2007 with special emphasis on the recent trends and gives details about the experimental conditions applied for analyses and the obtained analytical performance parameters.

References

Jun 10, 1994·Journal of Chromatography. a·R R ChadwickR B Nelson
May 31, 1996·Journal of Chromatography. a·M J van der SchansF M Everaerts
Jun 1, 1996·Journal of Pharmaceutical and Biomedical Analysis·Y M LiJos Hoogmartens
May 1, 1997·Journal of Pharmaceutical and Biomedical Analysis·K A AssiB J Clark
May 1, 1997·Journal of Pharmaceutical and Biomedical Analysis·Y M LiJos Hoogmartens
May 1, 1997·Journal of Pharmaceutical and Biomedical Analysis·J Tjørnelund, Steen Honoré Hansen
Mar 28, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·A K Lalloo, I Kanfer
Apr 21, 1998·Journal of Pharmaceutical and Biomedical Analysis·S Sabah, Gerhard K E Scriba
May 8, 1998·Journal of Pharmaceutical and Biomedical Analysis·M J HilhorstG J de Jong
Apr 1, 1995·Journal of Pharmaceutical and Biomedical Analysis·Steen Honoré HansenJ Tjørnelund
Dec 24, 1998·Journal of Pharmaceutical and Biomedical Analysis·R PorràR Lecce
Jan 19, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·P CoufalM Webb
Dec 22, 1999·Electrophoresis·S H Chen, Y H Chen
Jan 15, 2000·Journal of Chromatography. a·Roberto GottiV Cavrini
Mar 4, 2000·Journal of Pharmaceutical and Biomedical Analysis·S Hillaert, W Van den Bossche
Jul 6, 2000·Electrophoresis·L G Blomberg, H Wan
Dec 6, 2000·Journal of Chromatography. a·E C GilJos Hoogmartens
Dec 6, 2000·Journal of Chromatography. a·X F LiN J Dovichi
Mar 22, 2001·Electrophoresis·E C GilJos Hoogmartens
May 15, 2002·Journal of Pharmaceutical and Biomedical Analysis·Nikolai Novatchev, Ulrike Holzgrabe
Jun 1, 2002·Journal of Pharmaceutical and Biomedical Analysis·Maike WedigUlrike Holzgrabe
Mar 5, 2003·Journal of Pharmaceutical and Biomedical Analysis·H FernándezCoral Barbas
Mar 15, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·John PetersenDeborah Payne
Aug 6, 2003·Journal of Chromatography. a·Chien-Hou WuYing-Ying Lin
Aug 30, 2003·Journal of Pharmaceutical and Biomedical Analysis·M G QuagliaE Bossù
Oct 11, 2003·Journal of Pharmaceutical and Biomedical Analysis·R Nageswara Rao, V Nagaraju
Dec 9, 2003·Electrophoresis·Chun-Che LinShu-Hui Chen
Mar 12, 2004·Journal of Pharmaceutical and Biomedical Analysis·María S Aurora PradoMarina F M Tavares
Mar 20, 2004·Journal of Pharmaceutical and Biomedical Analysis·A MohammadiR B Walker
Sep 10, 2004·Journal of Chromatography. a·Dirk Bandilla, Cameron D Skinner
Sep 10, 2004·Journal of Chromatography. a·Serena OrlandiniSalvatore Fanali
Nov 10, 2004·Journal of Chromatography. a·Katarzyna MichalskaStefan Tyski
Jun 7, 2005·Journal of Pharmaceutical and Biomedical Analysis·Steen Honoré Hansen, Zeinab Awad Sheribah
Jun 9, 2005·Journal of Separation Science·Debby MangelingsYvan Vander Heyden
Sep 1, 2005·Journal of Chromatography. a·Genowefa PajchelStefan Tyski
Nov 30, 2005·Electrophoresis·Wang-Chou Sung, Shu-Hui Chen
Nov 30, 2005·Electrophoresis·Christian W HuckGünther K Bonn
Jan 18, 2006·Journal of Pharmaceutical and Biomedical Analysis·Alexandre Zatkovskis CarvalhoAnn Van Schepdael
Mar 7, 2006·Journal of Pharmaceutical and Biomedical Analysis·Pham Thi Thanh HaAnn Van Schepdael
Mar 7, 2006·Journal of Chromatography. a·María Castro-PuyanaMaria Luisa Marina
May 10, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Gerhard BilekErnst Kenndler
May 24, 2006·Electrophoresis·Luis SaavedraCoral Barbas
May 24, 2006·Electrophoresis·Rukhsana JabeenJohn Petersen
May 24, 2006·Electrophoresis·Michael J LittlePieter K Roos
Jun 21, 2006·Electrophoresis·Kevin AltriaCari Sänger-van de Griend
Sep 15, 2006·Journal of Pharmaceutical and Biomedical Analysis·Yaser Bitar, Ulrike Holzgrabe
Dec 1, 2006·Electrophoresis·Manuel Silva
Dec 7, 2006·Electrophoresis·Laurent Geiser, Jean-Luc Veuthey
Dec 27, 2006·Advanced Drug Delivery Reviews·Mark D ArgentineBernard A Olsen
Jan 2, 2007·Advanced Drug Delivery Reviews·Arup K BasakLawrence Yu
Jan 16, 2007·Advanced Drug Delivery Reviews·Satinder Sut Ahuja
Jan 16, 2007·Journal of Pharmaceutical Sciences·Emad L Izake
Mar 27, 2007·Journal of Pharmaceutical and Biomedical Analysis·J A Bertinatto RodríguezL E Diaz
Apr 12, 2007·Electrophoresis·Maike SniehottaHarald Mischak
Apr 24, 2007·Electrophoresis·Heimo ScherzGünther K Bonn

Citations

May 4, 2010·Analytical and Bioanalytical Chemistry·Leena Suntornsuk
May 3, 2014·Journal of Pharmaceutical and Biomedical Analysis·Zeineb AturkiSalvatore Fanali
Oct 22, 2011·Journal of Pharmaceutical and Biomedical Analysis·Mohamed N El-AttugAnn Van Schepdael
Dec 7, 2010·Journal of Pharmaceutical and Biomedical Analysis·Gerhard K E Scriba
Aug 20, 2010·Journal of Pharmaceutical and Biomedical Analysis·Alexandre Zatkovskis CarvalhoAnn Van Schepdael
Jul 4, 2009·Journal of Pharmaceutical and Biomedical Analysis·Nino G KokiashviliGerhard K E Scriba
Dec 8, 2011·Electrophoresis·Heide R RabanesJoselito P Quirino
Dec 21, 2010·Electrophoresis·Petr GebauerPetr Bocek
May 20, 2014·Journal of Separation Science·Sille Stěpánová, Václav Kasicka
Aug 25, 2015·Analytical and Bioanalytical Chemistry·Sandra FurlanettoSergio Pinzauti
Feb 28, 2018·Metallomics : Integrated Biometal Science·Hannah U HoltkampChristian G Hartinger
Jun 19, 2018·Journal of Chromatographic Science·Nathalie R WingertMartin Steppe
May 8, 2009·Analytical Chemistry·R K Gilpin, C S Gilpin

Related Concepts

Anti-Inflammatory Agents
Antineoplastic Agents
Cardiovascular Agents
Central Nervous System Agents
Pharmaceutical Preparations
Antihistamines, Classical
Electrophoresis, Capillary
Blood Capillaries
Electrophoresis
Ions

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.