IMRT dose escalation for positive para-aortic lymph nodes in patients with locally advanced cervical cancer while reducing dose to bone marrow and other organs at risk

International Journal of Radiation Oncology, Biology, Physics
Raef S AhmedJohn B Fiveash

Abstract

To evaluate the feasibility of dose-escalated para-aortic lymph node (PALN) intensity modulated radiation therapy (IMRT) in reducing the dose to bone marrow, bowel, spinal cord, and kidneys, compared with conventional radiation techniques of PALNs in patients with locally advanced cervical cancer and PALN metastases. Computed tomography scans and MRI studies of 5 cervical cancer patients with PALN involvement were transferred to an IMRT treatment planning workstation (Eclipse/Helios) for image fusion and definition of target volumes and critical structures. The positive PALNs identified on fused computed tomography-magnetic resonance images were defined as the gross target volume (GTV), and the PALN region was defined as the planning target volume. There were 2 distinct treatment regions: the PALN region superior to the isocenter and the whole-pelvis region inferior to the isocenter. Three treatment planning techniques were compared: AP/PA (both regions), 4-field box (both regions), and PALN-IMRT with 4-field box to the whole-pelvis field. With IMRT, the radiation dose to the GTV was escalated from the conventional 45 Gy to 60 Gy (2.4 Gy/fraction), whereas the planning target volume and whole-pelvis region received 45 Gy. The t...Continue Reading

References

Jul 30, 1995·International Journal of Radiation Oncology, Biology, Physics·D G PetereitD A Buchler
Jun 2, 1998·International Journal of Radiation Oncology, Biology, Physics·C A PerezM A Lockett
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A PetersD S Alberts
Nov 13, 2001·International Journal of Radiation Oncology, Biology, Physics·P W GrigsbyP Eifel
Dec 3, 2002·International Journal of Radiation Oncology, Biology, Physics·Clark J BrixeyArno J Mundt
Dec 31, 2002·International Journal of Radiation Oncology, Biology, Physics·Sasa MuticDaniel A Low
Jul 23, 2003·International Journal of Radiation Oncology, Biology, Physics·Arno J MundtJohn C Roeske

❮ Previous
Next ❯

Citations

Jun 10, 2006·European Journal of Nuclear Medicine and Molecular Imaging·J G RajendranD A Mankoff
Aug 12, 2005·Current Opinion in Oncology·Luis A Rojas-Espaillat, Peter G Rose
Oct 11, 2008·American Journal of Clinical Oncology·Dwight E HeronRyan P Smith
Jul 1, 2008·Biomedical Imaging and Intervention Journal·D E HeronJ W Mucenski
Oct 1, 2006·Journal of Medical Physics·Tomas KronJerry Battista
Nov 7, 2012·Medical Physics·Slobodan Devic
Sep 10, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·M L YapM Milosevic
Feb 24, 2016·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Craig BadenRobert Kim
Oct 4, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Shyam Kishore ShrivastavaKailash Narayan
Apr 14, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S Renard-OldriniD Peiffert
Dec 21, 2010·International Journal of Radiation Oncology, Biology, Physics·Albert J ChangJulie K Schwarz
Aug 17, 2010·International Journal of Radiation Oncology, Biology, Physics·Michael D HasselleLoren K Mell
Jul 6, 2010·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·F Drouet, J-L Lagrange
May 18, 2010·International Journal of Radiation Oncology, Biology, Physics·Karen LimUNKNOWN Gyn IMRT Consortium
May 18, 2010·International Journal of Radiation Oncology, Biology, Physics·James A HaymanMichael Mac Manus
Aug 22, 2009·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·I Barillot
Apr 14, 2009·International Journal of Radiation Oncology, Biology, Physics·Karen LimMichael Milosevic
Dec 9, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·A WhittonE Green
Jul 22, 2008·International Journal of Radiation Oncology, Biology, Physics·Loren K MellBulent Aydogan
Apr 4, 2006·Hematology/oncology Clinics of North America·Ryan P SmithNing J Yue
May 30, 2006·Hematology/oncology Clinics of North America·Kristin A Bradley, Daniel G Petereit
Jun 25, 2009·European Journal of Cancer Care·C KuemperA Strauss
Aug 27, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·E Jouglar, I Barillot
Nov 26, 2015·Radiation Oncology·Nikola CihoricKristina Lössl
May 30, 2006·International Journal of Radiation Oncology, Biology, Physics·Joseph K SalamaNeil Mehta
Jul 19, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·John C RoeskeArno J Mundt
Oct 5, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Shyam Kishore ShrivastavaKailash Narayan
Jan 21, 2015·Critical Reviews in Oncology/hematology·Rockne HymelCharles B Simone
Jan 15, 2014·International Journal of Radiation Oncology, Biology, Physics·Jonathan VermaAnn H Klopp
Feb 27, 2007·International Journal of Radiation Oncology, Biology, Physics·Sushil BeriwalRobert P Edwards
May 2, 2013·Gynecologic Oncology·Aaron WagnerDavid Gaffney
May 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Youngyih HanWon Park
Aug 21, 2010·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S VieillotD Azria

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.