IMVAMUNE® and ACAM2000® Provide Different Protection against Disease When Administered Postexposure in an Intranasal Monkeypox Challenge Prairie Dog Model

Vaccines
M Shannon KecklerInger K Damon

Abstract

The protection provided by smallpox vaccines when used after exposure to Orthopoxviruses is poorly understood. Postexposu re administration of 1st generation smallpox vaccines was effective during eradication. However, historical epidemiological reports and animal studies on postexposure vaccination are difficult to extrapolate to today's populations, and 2nd and 3rd generation vaccines, developed after eradication, have not been widely tested in postexposure vaccination scenarios. In addition to concerns about preparedness for a potential malevolent reintroduction of variola virus, humans are becoming increasingly exposed to naturally occurring zoonotic orthopoxviruses and, following these exposures, disease severity is worse in individuals who never received smallpox vaccination. This study investigated whether postexposure vaccination of prairie dogs with 2nd and 3rd generation smallpox vaccines was protective against monkeypox disease in four exposure scenarios. We infected animals with monkeypox virus at doses of 104 pfu (2× LD50) or 106 pfu (170× LD50) and vaccinated the animals with IMVAMUNE® or ACAM2000® either 1 or 3 days after challenge. Our results indicated that postexposure vaccination protected the animals to some...Continue Reading

References

Sep 1, 1972·The Journal of Pediatrics·D T Karzon
Apr 28, 2004·Emerging Infectious Diseases·Jeannette GuarnerUNKNOWN Veterinary Monkeypox Virus Working Group
Apr 15, 2005·Emerging Infectious Diseases·Shu-Yuan XiaoRobert B Tesh
Sep 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Carla OseroffAlessandro Sette
Sep 28, 2005·The Journal of General Virology·Anna M LikosInger K Damon
May 30, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Yu LiInger K Damon
Apr 10, 2008·The Journal of Clinical Investigation·Christofer SamuelssonHubertus Hochrein
Aug 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patricia L EarlBernard Moss
Jan 15, 2009·The Journal of General Virology·Christina L HutsonRussell L Regnery
Dec 1, 2009·Human Vaccines·Nir Paran, Gerd Sutter
Aug 5, 2010·Veterinary Pathology·J L ChapmanJ W Raymond
Sep 2, 2010·Proceedings of the National Academy of Sciences of the United States of America·Anne W RimoinJean-Jacques Muyembe
Oct 23, 2010·The Journal of General Virology·Aysegul Nalca, Donald K Nichols
Jan 14, 2012·Trends in Microbiology·Mary G Reynolds, Inger K Damon
May 18, 2012·Clinical and Vaccine Immunology : CVI·Christine M HughesInger K Damon
Jun 13, 2012·Methods in Molecular Biology·David EstebanR Mark Buller
Mar 26, 2015·The New England Journal of Medicine·Neil M VoraDarin S Carroll
May 7, 2015·Transboundary and Emerging Diseases·A A SergeevA N Sergeev

❮ Previous
Next ❯

Methods Mentioned

BETA
blood collection
PCR
ELISA

Software Mentioned

Prism
Genepix Pro
Elispot
GraphPad
ArrayScan HCS Reader

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.