In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype

Arthritis Research & Therapy
Hector ChinoyUK Adult Onset Myositis Immunogenetic Collaboration (AOMIC)

Abstract

The aim of this study was to investigate HLA class II associations in polymyositis (PM) and dermatomyositis (DM), and to determine how these associations influence clinical and serological differences. DNA samples were obtained from 225 UK Caucasian idiopathic inflammatory myopathy patients (PM = 117, DM = 108) and compared with 537 randomly selected UK Caucasian controls. All cases had also been assessed for the presence of related malignancy and interstitial lung disease (ILD), and a number of myositis-specific/myositis-associated antibodies (MSAs/MAAs). Subjects were genotyped for HLA-DRB1, DQA1 and DQB1. HLA-DRB1*03, DQA1*05 and DQB1*02 were associated with an increased risk for both PM and DM. The HLA-DRB1*03-DQA1*05-DQB1*02 haplotype demonstrated strong association with ILD, irrespective of myositis subtype or presence of anti-aminoacyl-transfer RNA synthetase antibodies. The HLA-DRB1*07-DQA1*02-DQB1*02 haplotype was associated with risk for anti-Mi-2 antibodies, and discriminated PM from DM (odds ratio 0.3, 95% confidence interval 0.1-0.6), even in anti-Mi-2 negative patients. Other MSA/MAAs showed specific associations with other HLA class II haplotypes, irrespective of myositis subtype. There were no genotype, haplotyp...Continue Reading

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Citations

Aug 20, 2009·Rheumatology·Hector ChinoyUNKNOWN UK Adult Onset Myositis Immunogenetic Collaboration & UK Juvenile Dermatomyositis Research Group
Jan 3, 2012·Rheumatology·Hector ChinoyUNKNOWN UK Adult Onset Myositis Immunogenetic Consortium and UK Juvenile Dermatomyositis Research Group
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Apr 5, 2007·Annals of the Rheumatic Diseases·Hector ChinoyUNKNOWN UK Adult Onset Myositis Immunogenetic Collaboration
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Jun 11, 2011·Arthritis Research & Therapy·Hector ChinoyRobert G Cooper
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Methods Mentioned

BETA
immunoprecipitation
PCR
genotyping

Software Mentioned

CLUMP
Stata
AOMIC
HelixTree

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