In-Body Network Biomedical Applications: From Modeling to Experimentation

IEEE Transactions on Nanobioscience
Valeria LoscriAnna Maria Vegni

Abstract

Innovative diagnostic approaches and therapies are more and more based on the use of injections or oral delivery of nanoparticle sized substances. For a better understanding of the overall phenomena, aiming to facilitate a safe application at large scale, the development of accurate models and analysis techniques are required. These techniques take into consideration different aspects of the overall process: accurate numerical modeling of the different phases of the nanoparticles in the body, and knowledge of the local environment, that can be varying very fast within a short-range in the body itself. Such aspects should be taken into account to correctly predict the amount of drug and its timely release for the specific disease. Deep and accurate analysis of the interaction between the nanoparticles and the biological fluid where the nanoparticles are immersed is mandatory for an efficient correlation of all these aspects. Because of their biocompatibility, in this paper, we focus our attention on systems of Titanium (Ti), and its oxide (e.g., TiO2), given their specific features in terms of density, lack of cytotoxic effects, etc. Specifically, we present the study and design of an in-body system by characterizing each of the...Continue Reading

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Apr 22, 2015·IEEE Transactions on Nanobioscience·Valeria Loscrí, Anna Maria Vegni
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Nov 4, 2015·IEEE Transactions on Nanobioscience·Mauro FemminellaAthanasios Vasilakos

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