In-cell recordings by extracellular microelectrodes.

Nature Methods
Aviad HaiMicha E Spira

Abstract

Current extracellular multisite recordings suffer from low signal-to-noise ratio, limiting the monitoring to action potentials, and preclude detection of subthreshold synaptic potentials. Here we report an approach to induce Aplysia californica neurons to actively engulf protruding microelectrodes, providing 'in-cell recordings' of subthreshold synaptic and action potentials with signal-to-noise ratio that matches that of conventional intracellular recordings. Implementation of this approach may open new vistas in neuroscience and biomedical applications.

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Citations

Jun 28, 2012·Nano Letters·Huanan ZhangNicholas A Kotov
May 16, 2012·Nano Letters·Ruixuan GaoCharles M Lieber
Oct 4, 2013·Nano Letters·Francesca SantoroAndreas Offenhäusser
Feb 6, 2013·Nature Nanotechnology·Micha E Spira, Aviad Hai
Feb 14, 2012·Nature Nanotechnology·Chong XieBianxiao Cui
Aug 21, 2012·PloS One·Matthew R Angle, Andreas T Schaefer
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Feb 16, 2012·Journal of Neural Engineering·Ling WangEnric Claverol-Tinturé

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