In Children and Youth with Mild and Moderate Traumatic Brain Injury, Glial Fibrillary Acidic Protein Out-Performs S100β in Detecting Traumatic Intracranial Lesions on Computed Tomography

Journal of Neurotrauma
Linda PapaMark Zonfrillo

Abstract

In adults, glial fibrillary acidic protein (GFAP) has been shown to out-perform S100β in detecting intracranial lesions on computed tomography (CT) in mild traumatic brain injury (TBI). This study examined the ability of GFAP and S100β to detect intracranial lesions on CT in children and youth involved in trauma. This prospective cohort study enrolled a convenience sample of children and youth at two pediatric and one adult Level 1 trauma centers following trauma, including both those with and without head trauma. Serum samples were obtained within 6 h of injury. The primary outcome was the presence of traumatic intracranial lesions on CT scan. There were 155 pediatric trauma patients enrolled, 114 (74%) had head trauma and 41 (26%) had no head trauma. Out of the 92 patients who had a head CT, eight (9%) had intracranial lesions. The area under the receiver operating characteristic curve (AUC) for distinguishing head trauma from no head trauma for GFAP was 0.84 (0.77-0.91) and for S100β was 0.64 (0.55-0.74; p<0.001). Similarly, the AUC for predicting intracranial lesions on CT for GFAP was 0.85 (0.72-0.98) versus 0.67 (0.50-0.85) for S100β (p=0.013). Additionally, we assessed the performance of GFAP and S100β in predicting intr...Continue Reading

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Citations

Apr 22, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Ihsan CetinOmer Faruk Ozer
Jul 13, 2017·Journal of Neurotrauma·Timothy B MeierMichael A McCrea
Nov 14, 2018·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Amit SinglaR Shane Tubbs
Aug 3, 2016·Sports Medicine and Arthroscopy Review·Linda Papa
Jun 1, 2018·BioMed Research International·Fatos M KelmendiAfrim Kotori
Oct 16, 2015·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Linda PapaManoj K Mittal
May 3, 2018·Pediatrics·Charlotte OrisDamien Bouvier

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays
ELISA

Software Mentioned

PASW

Related Concepts

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Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.