In contrast to its anti-inflammatory and anti-apoptotic peripheral effect, levosimendan failed to induce a long-term neuroprotective effect in a rat model of mild septic encephalopathy: a pilot study

Neuroscience Letters
Konstanze PlaschkeJürgen Kopitz

Abstract

Levosimendan shows protective myocardial characteristics and is administered to enhance cardiac contractility in patients. However, currently little is known about levosimendan's effect on brain. The aim of this pilot study was to investigate the long-term effect of levosimendan on brain and during mild rat sepsis in comparison to its peripheral mode of action. Adult rats (n=40) were divided into four groups with n=10 per group: (I) sham, (II) levosimendan (283 μg/kg body weight i.v.), (III) lipopolysaccharide (LPS, 8 mg/kg body weight i.p.), and (IV) LPS+levosimendan. Levosimendan was given 24h after injecting LPS. Psychometric investigations were conducted using a Morris water maze (MWM) and a holeboard test. In cerebral and splenic tissue, IL-1β, Il-6, TNFalpha levels, and apoptosis were determined; cerebral tissue corticosterone concentration was measured 6 days after injecting LPS. Blood cytokine concentrations were determined 1 day and 6 days after injecting LPS. Rats that received an LPS injection spent more time in the outer zone of the MWM according to increased cerebral corticosterone levels, and showed decreased cognitive abilities. LPS induced a reduction in body weight, increased splenic apoptosis and blood cytokin...Continue Reading

References

Nov 1, 1990·The Journal of Surgical Research·T TaniguchiT Tanaka
Jun 1, 1990·The Journal of Surgical Research·W ErtelF W Schildberg
May 1, 1984·Journal of Neuroscience Methods·R Morris
Oct 25, 2002·International Journal of Clinical Pharmacology and Therapeutics·M KivikkoP J Pentikäinen
Apr 8, 2003·Current Pharmaceutical Design·Weihong Pan, Abba J Kastin
Oct 19, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Saila AntilaHarry Scheinin
Apr 12, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kai ZacharowskiStefan R Bornstein
Aug 10, 2006·Stress : the International Journal on the Biology of Stress·Konstanze PlaschkeAngelika Bierhaus
Sep 12, 2006·Cardiovascular Research·James F BuckleyLucie H Clapp
Jul 27, 2007·American Journal of Hematology·Kürşat KaptanErsoy Işik
Sep 17, 2008·Journal of Neuroinflammation·Alexander SemmlerMichael T Heneka
Sep 30, 2008·Experimental Neurology·Konstanze PlaschkeHugo H Marti
Apr 16, 2009·Intensive Care Medicine·Patrick ScheiermannChristian Hofstetter
May 12, 2009·Acta Anaesthesiologica Scandinavica·M HeinR Rossaint
Sep 9, 2009·Brain, Behavior, and Immunity·William A Banks, Sandra M Robinson
Feb 6, 2010·Critical Care Medicine·Emanuele IacoboneTarek Sharshar
Apr 30, 2010·International Journal of Molecular Medicine·Mian ZhouPing Wang
Jan 12, 2011·Neurochemistry International·Alexander JacobJessy J Alexander

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Citations

Nov 30, 2014·Critical Care : the Official Journal of the Critical Care Forum·Cheng-Ming TsaoChin-Chen Wu
Nov 28, 2017·Behavioural Pharmacology·Abeer M Rababa'hAla'a Atmeh
Mar 9, 2019·Current Molecular Pharmacology·Abeer M Rababa'hMera Ababneh
Mar 28, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Serdar DemirganAyşin Selcan

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