PMID: 11926283Apr 3, 2002Paper

In contrast to neuronal NOS-I, the inducible NOS-II expression in aging brains is modifled by enriched environmental conditions

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Heidegard HilbigHans-Jïrgen Bidmon

Abstract

Changes in the expression of the nitric oxide synthase isoforms (NOS) have been implicated in age-related neurodegeneration, although mechanisms responsible for specific differences such as reduced cognitive and motor functions are not well understood. Immunohistochemical examination of the age-dependent NOS-I and NOS-II expression in aging rats at 3, 12, 24, 36 months of age as well as in 36 months old rats who spent their last 3 months in an enriched environment, revealed a significant decrease in NOS-I expression with aging. In contrast, NOS-II increased at 36 months. Old rats kept under enriched environmental conditions, however, showed strongly reduced NOS-II expression. These results indicate that both NOS-I and II may contribute to age-related degenerative processes, but in contrast to NOS-I the age-dependent changes of NOS-II are reduced or even reversed by stimulating environmental conditions.

References

Jan 1, 1995·Annual Review of Physiology·J Garthwaite, C L Boulton
Feb 15, 1995·Neuroreport·F SpenglerH R Dinse
May 1, 1997·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·H KuoD K Ingram
Jul 1, 1997·Experimental Gerontology·S M McCann
Sep 18, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J P DreierU Dirnagl
Nov 24, 1999·Free Radical Biology & Medicine·O W Griffith
Mar 11, 2000·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·H ObrigA Villringer

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Citations

Mar 10, 2010·Molecular Neurobiology·Katarzyna Urszula Domek-Łopacińska, Joanna B Strosznajder
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ali Mohammad Pourbagher-ShahriJurga Bernatoniene

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