In defence of the carbon monoxide transfer coefficient Kco (TL/VA)

The European Respiratory Journal
J M Hughes, N B Pride

Abstract

The carbon monoxide transfer factor (TL,co) is the product of the two primary measurements during breath-holding, the CO transfer coefficient (Kco) and the alveolar volume (VA). Kco is essentially the rate constant for alveolar CO uptake (Krogh's kco), and in healthy subjects, increases when VA is reduced by submaximal inflation, or when pulmonary blood flow increases. Recently, new reference values were proposed for clinical use which included the observed VA at full inflation; this was claimed to "eliminate the need for Kco". In this commentary, some mechanisms e.g. respiratory muscle weakness, lung resection, diffuse alveolar damage and airflow obstruction, which decrease or increase total lung capacity (TLC) are reviewed. Even when alveolar structure and function are normal, the change in Kco at a given VA varies according to the underlying pathophysiological mechanism. The advantages and disadvantages of normalizing Kco and TL,co to predisease predicted TLC or to the patient's actual VA (using lack of expansion or loss of alveolar units models) are considered. Examination of carbon monoxide transfer coefficient and alveolar volume separately provides information on disease pathophysiology which cannot be obtained from thei...Continue Reading

Citations

Dec 7, 2007·European Journal of Applied Physiology·G MiserocchiE Beretta
Mar 24, 2009·Clinical Reviews in Allergy & Immunology·Cristine E Berry, Robert A Wise
Dec 22, 2009·Critical Care Medicine·Luciano Gattinoni, Alessandro Protti
Mar 27, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jenny C NgaiDavid S Hui
Feb 15, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Bin-Miao LiangYu-Lin Feng
Apr 28, 2012·American Journal of Respiratory and Critical Care Medicine·J Michael B Hughes, Neil B Pride
Nov 8, 2005·Revue des maladies respiratoires·S GuillotJ Dassonville
Dec 2, 2015·American Journal of Respiratory Cell and Molecular Biology·Kara N GossShawn K Ahlfeld
May 25, 2013·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jun YangMaureen P Swanney
Oct 24, 2006·Respiratory Medicine·David A KaminskyPeter W Callas
Apr 2, 2011·Respiratory Medicine·Lize KiakouamaJean-François Cordier
Jan 19, 2007·Respiratory Medicine·Ivo van der LeeJan-Willem J Lammers
Dec 6, 2016·Respiratory Physiology & Neurobiology·Colin Borland, Hervé Guénard
Nov 22, 2007·Chronic Respiratory Disease·J M B Hughes
May 11, 2010·Respiration; International Review of Thoracic Diseases·Irina EnacheAnne Charloux
Jun 13, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nishard AbdeenGiles Santyr
Jan 4, 2017·The European Respiratory Journal·Brian L GrahamJack Wanger
Aug 9, 2005·Pediatric Blood & Cancer·Paul A HoffmeisterJean E Sanders
Apr 12, 2019·ERJ Open Research·Martina NassifRobbert J de Winter
May 15, 2013·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Mauricio González-GarcíaHumberto Varon
Jan 11, 2018·Expert Review of Clinical Immunology·Peter M George, Athol U Wells
Apr 3, 2021·European Journal of Radiology·Maurizio BalbiSandro Sironi
Dec 18, 2003·Pediatric Pulmonology·Peter J F M MerkusJohan C de Jongste

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