In-depth characterization of monocyte subsets during the course of healthy pregnancy.

Journal of Reproductive Immunology
Caroline PflitschSusanne Maria Ziegler

Abstract

Pregnancy represents an immunological challenge for the maternal immune system. Pregnancy augments innate immune responses, and particularly monocytes contribute to maintaining the balance between pro- and anti-inflammatory immune responses required for the successful sequence of distinct immunological phases throughout pregnancy. Nonetheless, studies that focus on the heterogeneity of monocytes and analyze the alteration of monocyte subsets in a longitudinal approach throughout healthy pregnancies have remained scarce. In this study, we characterized the gradual phenotypic changes of monocyte subsets and the secretory potential of bulk monocytes in peripheral blood mononuclear cells of healthy pregnant women from a population-based prospective birth cohort study. Blood samples at predefined time points were analyzed using flow cytometry for in-depth characterization of monocyte subsets, which confirmed a shift from classical towards intermediate monocytes throughout pregnancy. Principal component analysis revealed characteristic phenotypic changes on monocyte subsets, especially on the intermediate monocyte subset, throughout pregnancy. Pregnancy-related hormones were measured in serum and β-human chorionic gonadotropin levels...Continue Reading

Citations

Feb 16, 2021·Frontiers in Immunology·Rebecca ShepherdBoris Novakovic
Feb 26, 2021·Journal of Perinatal Medicine·Sebastian HäuslerSara Fill Malfertheiner
Dec 11, 2021·Journal of Leukocyte Biology·Marcia Arenas-HernandezNardhy Gomez-Lopez

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