In-depth study of Mollivirus sibericum, a new 30,000-y-old giant virus infecting Acanthamoeba

Proceedings of the National Academy of Sciences of the United States of America
Matthieu LegendreJean-Michel Claverie

Abstract

Acanthamoeba species are infected by the largest known DNA viruses. These include icosahedral Mimiviruses, amphora-shaped Pandoraviruses, and Pithovirus sibericum, the latter one isolated from 30,000-y-old permafrost. Mollivirus sibericum, a fourth type of giant virus, was isolated from the same permafrost sample. Its approximately spherical virion (0.6-µm diameter) encloses a 651-kb GC-rich genome encoding 523 proteins of which 64% are ORFans; 16% have their closest homolog in Pandoraviruses and 10% in Acanthamoeba castellanii probably through horizontal gene transfer. The Mollivirus nucleocytoplasmic replication cycle was analyzed using a combination of "omic" approaches that revealed how the virus highjacks its host machinery to actively replicate. Surprisingly, the host's ribosomal proteins are packaged in the virion. Metagenomic analysis of the permafrost sample uncovered the presence of both viruses, yet in very low amount. The fact that two different viruses retain their infectivity in prehistorical permafrost layers should be of concern in a context of global warming. Giant viruses' diversity remains to be fully explored.

References

Jan 23, 1999·Nature Genetics·B SnelM A Huynen
Dec 26, 2001·Nucleic Acids Research·Aron Marchler-BauerStephen H Bryant
Mar 27, 2003·Traffic·Urs F Greber, Ariberto Fassati
Mar 29, 2003·Science·Bernard La ScolaDidier Raoult
Sep 4, 2003·Genome Research·Li LiDavid S Roos
Sep 13, 2003·BMC Bioinformatics·Roman L TatusovDarren A Natale
May 18, 2004·BMC Bioinformatics·Ian Korf
Jun 25, 2004·Nucleic Acids Research·Aron Marchler-Bauer, Stephen H Bryant
Oct 16, 2004·Science·Didier RaoultJean-Michel Claverie
Jul 12, 2005·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·A V ShatilovichD A Gilichinskiĭ
Nov 30, 2005·Nucleic Acids Research·Alexandre LomsadzeMark Borodovsky
Sep 15, 2006·Journal of Virology·Patricia RenestoJean-Michel Claverie
Feb 21, 2007·Bioinformatics·Jan KrumsiekThomas Rattei
Jun 8, 2007·Microbiology and Molecular Biology Reviews : MMBR·Karen L Maxwell, Lori Frappier
Nov 21, 2007·Genome Research·Brandi L CantarelMark Yandell
Feb 17, 2009·Current Topics in Microbiology and Immunology·J M ClaverieH Ogata
Aug 6, 2009·Annual Review of Genetics·Jean-Michel Claverie, Chantal Abergel
Dec 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mickaël BoyerDidier Raoult
Mar 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yael MutsafiAbraham Minsky
Jun 2, 2010·Bioinformatics·James K Bonfield, Andrew Whitwham
Oct 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Matthias G FischerCurtis A Suttle
Mar 12, 2011·Environmental Microbiology·Vincent ThomasGilbert Greub
Oct 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Defne ArslanJean-Michel Claverie
Dec 14, 2011·Genome Research·Jared T Simpson, Richard Durbin
Mar 6, 2012·Nature Methods·Ben Langmead, Steven L Salzberg
Nov 29, 2012·Archives of Virology·Philippe ColsonDidier Raoult
Jun 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Sebastien SantiniJean-Michel Claverie
Mar 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Matthieu LegendreJean-Michel Claverie
Nov 16, 2014·Nucleic Acids Research·UNKNOWN NCBI Resource Coordinators

❮ Previous
Next ❯

Citations

Feb 7, 2016·Current Opinion in Microbiology·S HalaryC Desnues
Dec 23, 2015·International Journal of Molecular Sciences·Francesco PiacenteMichela G Tonetti
Mar 15, 2016·Studies in History and Philosophy of Biological and Biomedical Sciences·Jean-Michel Claverie, Chantal Abergel
Mar 22, 2016·Current Opinion in Microbiology·Matthias G Fischer
Apr 6, 2016·Frontiers in Microbiology·Sarah AherfiDidier Raoult
Sep 24, 2015·FEMS Microbiology Reviews·Chantal AbergelJean-Michel Claverie
Apr 5, 2016·Current Opinion in Microbiology·Romain Blanc-Mathieu, Hiroyuki Ogata
Apr 4, 2016·Current Opinion in Microbiology·Jacques Yaacoub Bou KhalilBernard La Scola
Apr 4, 2016·Current Opinion in Microbiology·Rodrigo Araújo Lima RodriguesErna Geessien Kroon
May 1, 2016·Current Opinion in Microbiology·Philippe ColsonDidier Raoult
May 10, 2016·Trends in Microbiology·Philip E LongJillian F Banfield
Jun 19, 2016·Microbial Pathogenesis·Perrine HugonDidier Raoult
Jul 20, 2016·Journal of Biological Research·Krishna Khairnar
Nov 2, 2016·Viruses·Leena H BajraiBernard La Scola
Nov 26, 2016·Viruses·Meriem BeklizBernard La Scola
Jan 13, 2017·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Gabriel Magno de Freitas AlmeidaJonatas Santos Abrahao
Jan 25, 2017·Viruses·Graziele Pereira OliveiraJônatas Santos Abrahão
Feb 17, 2017·PLoS Genetics·Jônatas Santos AbrahãoBernard La Scola
Feb 28, 2017·Nature Reviews. Microbiology·Philippe ColsonDidier Raoult
Oct 16, 2016·Scientific Reports·Raíssa Nunes Dos SantosAna Cláudia Franco
Apr 22, 2017·Nature Communications·Elisabeth FabreChantal Abergel
Apr 27, 2017·Viruses·James L Van EttenGarry A Duncan
May 18, 2017·Annals of Human Biology·Charlotte J HouldcroftSimon J Underdown
Jan 4, 2017·Médecine sciences : M/S·Jean-Michel Claverie, Chantal Abergel
Jun 24, 2017·European Journal of Internal Medicine·Philippe CharlierSaudamini Deo
Jan 26, 2018·Virology Journal·Ana Cláudia Dos S P AndradeJônatas S Abrahão
Nov 17, 2017·Journal of Molecular Evolution·Ankita GuptaKiran Kondabagil
May 29, 2018·Microbes and Environments·Tomoko MiharaHiroyuki Ogata
Apr 28, 2017·Journal of Virology·Julien AndreaniBernard La Scola
Mar 18, 2016·Journal of Virology·Thalita Souza ArantesJônatas Santos Abrahão
Jan 10, 2019·Médecine sciences : M/S·Jean-Michel ClaverieMatthieu Legendre
Dec 14, 2018·Journal of Virology·Ana Cláudia Dos Santos Pereira AndradeJônatas Santos Abrahão
Mar 1, 2018·Nature Communications·Jônatas AbrahãoBernard La Scola
Mar 7, 2018·Scientific Reports·Ludmila Karen Dos Santos SilvaJônatas Santos Abrahão

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Matthieu LegendreJean-Michel Claverie
© 2021 Meta ULC. All rights reserved