In depth study of phenolic profile and PTP-1B inhibitory power of cold-pressed grape seed oils of different varieties

Food Chemistry
Lorenzo CecchiNadia Mulinacci

Abstract

This paper investigates the phenolic composition of 17 monocultivar commercial cold-pressed grape seed oils. Chromatographic profiles showed the presence of more than 28 molecules, 11 of which were successfully identified by HPLC-DAD-MS-TOF and HPLC-FLD analysis. Pinoresinol, ethyl caffeate and ethyl gallate were detected for the first time in these oils. The total phenolic content ranged between 0.83 mg/kg for Viognier sample to 15.16 mg/kg for Merlot org sample. The detected ethyl esters can be suggested as markers to evaluate the intensity of fermentation in grape seeds before oil extraction, and to control the sensorial quality of the produced oils. In addition, the inhibitory power of these phenolic extracts against Protein Tyrosine Phosphatase 1B enzyme (PTP-1B), overexpressed in type-two diabetes, was investigated for the first time. Data highlighted a good correlation between total phenolic content and inhibitory power, with pinoresinol, p-coumaric acid and quercetin making the greater contributions.

Citations

Nov 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marina FidelisDaniel Granato
Jul 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lorenzo CecchiMaria Camilla Bergonzi
Feb 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vika GabeAnwar Rayan
Jun 13, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria BellumoriNadia Mulinacci
Mar 20, 2021·Environmental Pollution·Pankaj ChowdharyPreeti Chaturvedi
Oct 10, 2021·Plant Foods for Human Nutrition·Kateřina DadákováJiří Sochor

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