In developing brown adipose tissue c-myc protooncogene expression is restricted to early differentiation stages.

Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists
U HirningH Hameister

Abstract

The expression pattern of the c-myc protooncogene during fetal development of the mouse was studied by RNA in situ hybridization to tissue sections. In day 15.5 post coitum (p.c.) and day 16.5 p.c. embryos, distinct c-myc expression was observed at the site of brown adipose tissue development. High c-myc expression at this site coincides with expression of the NADH-dependent, cytosolic form of glycerol-3-phosphate dehydrogenase (GPDH). Fat deposition in the form of single small droplets occurs as early as day 15.5 p.c. At earlier stages (day 14.5 p.c. and earlier) the mesenchymal precursor cells at this site show neither c-myc nor GPDH expression. During fetal development the brown adipose tissue increases enormously in size. GPDH expression increases concomitantly as does multilocular fat deposition. However, c-myc expression is not detectable in brown adipose tissue later than day 16.5 p.c.

References

Sep 1, 1985·Experimental Cell Research·T SejersenN R Ringertz
Sep 1, 1987·Experimental Cell Research·N DenisA Kitzis
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A E Griep, H Westphal
Jul 1, 1988·Genes & Development·W H LandschulzS L McKnight
Jun 1, 1988·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·C Y TzenR E Scott
Oct 1, 1986·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·H HaunerE F Pfeiffer
Jun 1, 1986·The American Journal of Physiology·L J BukowieckiA J Collet
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S Pfeifer-OhlssonR Ohlsson
Oct 1, 1968·Journal of Cellular Physiology·W J RutterT G Sanders
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E H WestinR C Gallo

❮ Previous
Next ❯

Citations

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B C PariaG K Andrews
Aug 31, 2013·Developmental Cell·Jun Hong ParkSean Bong Lee
Feb 1, 1989·Biochemical Genetics·S P SchifferD F Patterson
Dec 11, 2020·Cells·Yun Kyung LeeJun Hong Park
Aug 28, 2021·Biomedicines·Ekaterina Mikhailovna StasevichAnton Markovich Schwartz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.