In experimental diabetes the decrease in the eye of lens carnitine levels is an early important and selective event

Experimental Eye Research
P PessottoG Peluso

Abstract

Carnitine is present in the eye tissues of the rabbit and the highest concentration is found in the lens. In streptozotocin-diabetic rats, the carnitine loss of the lens is an initial and important event. At 8 days after the induction of diabetes, the carnitine content in the rat lens was reduced by 63% compared to control. The loss of lens carnitine continued at 15 and 45 days after the induction. Total carnitine level in the serum was diminished by 15 days, and the reduction in percentage term was much lower in comparison to the loss of lens carnitine. In the rabbit after alloxan-diabetes induction, there is an extensive loss of carnitine in the lens: -85% after 4 months. The carnitine levels in the other eye tissues seem substantially unaffected. The loss of lens carnitine was present even with an inconsistent hyperglycaemia. No difference was found in serum carnitine levels between controls and alloxan-treated rabbits. The role of carnitine in lens is still unclear, but its loss may be related to the appearance of cataract. A derivative of carnitine, acetylcarnitine, might prevent the processes involved in the formation of cataracts by a pharmacological action, as has been shown for aspirin.

Citations

Apr 20, 2010·Nutrition & Metabolism·Judith L FlanaganQian Garrett
Apr 4, 2008·Journal of Clinical Biochemistry and Nutrition·Yoshikazu YoneiToshito Yoshioka
Jun 22, 1999·Experimental Eye Research·S Swamy-Mruthinti, A L Carter
Oct 13, 2000·Journal of Cellular Biochemistry·G PelusoM Calvani
Dec 17, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Arthur Stevens
Aug 18, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ibrahim KocerKorkmaz Serifoglu
Jan 22, 2009·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Nicola PescosolidoMasa Messano
Apr 28, 2009·Biological Trace Element Research·Nurhan GumralManuel F Flores-Arce
Jun 28, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G PelusoM Calvani
Oct 11, 2011·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Mariasilva EvangelistaNicola Pescosolido

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