In-feed resin acids reduce matrix metalloproteinase activity in the ileal mucosa of healthy broilers without inducing major effects on the gut microbiota

Veterinary Research
Marisol AguirreEvy Goossens

Abstract

The chicken gut is constantly exposed to harmful molecules and microorganisms which endanger the integrity of the intestinal wall. Strengthening intestinal mucosal integrity is a key target for feed additives that aim to promote intestinal health in broilers. Recently, dietary inclusion of resin-based products has been shown to increase broiler performance. However, the mode of action is still largely unexplored. Coniferous resin acids are known for their anti-microbial, anti-inflammatory and wound-healing properties, all properties that might support broiler intestinal health. In the current study, the effect of pure resin acids on broiler intestinal health was explored. Ross 308 broilers were fed a diet supplemented with coniferous resin acids for 22 days, after which the effect on both the intestinal microbiota as well as on the intestinal tissue morphology and activity of host collagenases was assessed. Dietary inclusion of resin acids did not alter the morphology of the healthy intestine and only minor effects on the intestinal microbiota were observed. However, resin acids-supplementation reduced both duodenal inflammatory T cell infiltration and small intestinal matrix metalloproteinase (MMP) activity towards collagen ty...Continue Reading

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Citations

May 18, 2020·Poultry Science·Annatachja De GrandeRichard Ducatelle
Nov 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia A LuchnikovaIrina B Ivshina
Mar 2, 2021·The Science of the Total Environment·Alexandra E LakingAn Martel

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Methods Mentioned

BETA
PCR
electrophoresis
Illumina sequencing
DNA assay
protein assay
Assay

Software Mentioned

DESeq
R
USEARCH
GraphPad Prism
PyNast
Quantity One
PANDAseq
QIIME
vegan
Leica Application Suite

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