In fetuses with isolated hydronephrosis, urinary beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase (NAG) have a limited role in the prediction of postnatal renal function

Prenatal Diagnosis
B TassisU Nicolini

Abstract

Seventy-one fetal urine samples were taken from the bladder or renal pelvis of 33 fetuses at 13-36 weeks' gestation with a diagnosis of urinary tract anomaly. Severe isolated hydronephrosis in the absence of an enlarged bladder was the indication for sampling in 12/33 fetuses (26 samples), who were retrospectively classified into three groups: normal, intermediate, and dysplastic, based on the evaluation of postnatal renal function or histology. For all samples, urinary sodium (Na+), calcium (Ca2+), creatinine, beta 2-microglobulin, and N-acetyl-beta-D-glucosaminidase (NAG) were measured. Among the 71 fetal urine samples, both beta 2-microglobulin and NAG correlated inversely with gestational age, Na+, and Ca2+, but not with creatinine concentrations. However, the correlation of urinary beta 2-microglobulin with gestational age was dependent on the Na+ and Ca2+ concentrations, whereas urinary NAG correlated significantly with urinary Na+ and Ca2+, and also with gestational age. In fetuses with isolated hydronephrosis, only Na+, and not Ca2+, was significantly related to both beta 2-microglobulin and NAG. Only Na+ and beta 2-microglobulin were significantly, and similarly, higher in both dysplastic and intermediate kidneys when ...Continue Reading

References

Jan 1, 1992·British Journal of Obstetrics and Gynaecology·U NicoliniJ Beacham
Mar 1, 1992·American Journal of Obstetrics and Gynecology·K H NicolaidesC F Moniz
May 1, 1990·American Journal of Obstetrics and Gynecology·T M CrombleholmeR A Filly
Feb 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·P E Evrin, L Wibell
Jan 1, 1970·Clinica Chimica Acta; International Journal of Clinical Chemistry·N DanceB Richards
Jan 1, 1993·American Journal of Obstetrics and Gynecology·S LipitzC H Rodeck
Jan 23, 1958·The Journal of Physiology·D P ALEXANDERF X WOHLZOGEN
Jan 1, 1961·The Biochemical Journal·D H LEABACK, P G WALKER

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Citations

Aug 26, 1998·Obstetrics and Gynecology Clinics of North America·D M Stamilio, M A Morgan

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