In-field and abscopal response after short-course radiation therapy in patients with metastatic Merkel cell carcinoma progressing on PD-1 checkpoint blockade: a case series

Journal for Immunotherapy of Cancer
Melody J XuSue S Yom

Abstract

Patients with metastatic Merkel cell carcinoma (mMCC) who experience disease progression on immunotherapy have limited additional standard options. Given evidence of synergism between radiation therapy (RT) and immunotherapy, two patients progressing on PD-1 inhibition were referred for short-course RT. Two patients were found to have progressive mMCC on PD-1 inhibitor therapy and were treated with single-fraction palliative RT. Both patients were observed to have local control at irradiated regions, as well as durable abscopal response at unirradiated, out-of-field, sites of metastatic disease. Short-course RT is a compelling strategy that could be a means to augment response in patients with mMCC who show progression on immune checkpoint blockade. Ongoing clinical trials are investigating the relationship between RT and immunotherapy in mMCC.

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Citations

Feb 21, 2019·American Journal of Clinical Dermatology·Mahtab Samimi
Dec 12, 2019·F1000Research·Caitlin G RobinsonSiegrid S Yu
Mar 2, 2019·Dermatology and Therapy·Alessia VillaniMassimiliano Scalvenzi
Jan 30, 2021·Future Oncology·Song Y ParkPaul Nghiem
Dec 11, 2020·International Journal of Molecular Sciences·Junko Takahashi, Shinsuke Nagasawa
May 29, 2020·Journal of the American Academy of Dermatology·Dulce M BarriosMario E Lacouture
Apr 4, 2021·Cancers·Ellen M ZwijnenburgJohannes H A M Kaanders
May 31, 2021·Journal of Medical Imaging and Radiation Oncology·Shaheen HasmatMichael J Veness
Jun 12, 2021·Journal of Cancer Research and Clinical Oncology·Morgan GuénoléUlrike Schick

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Methods Mentioned

BETA
biopsy
surgical resection

Clinical Trials Mentioned

NCT02821182
NCT02407171
NCT02659540
NCT02303990
NCT03071406

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