Abstract
Fatty acid ethyl esters (FAEEs) have been proposed as a marker of ethanol consumption because they can be detected for up to 24 hr after a moderate intake of ethanol, even though blood ethanol remains increased for only 8 hr. Therefore, this study investigated whether FAEEs can be found during a time period exceeding 24 hr in a group of patients who were hospitalized for ethanol detoxification. A second aim was to study the distribution of FAEEs between lipoproteins during that time. Serum samples of 12 patients with acute ethanol intoxication were assayed for FAEEs. Blood samples were drawn 8.2, 20.2, 32.2, and 44.2 hr after hospitalization. FAEEs were quantified by gas chromatography-mass spectrometry. Ethanol was no longer detectable after 20.2 hr from hospitalization, whereas FAEEs were still found after 32.2 and 44.2 hr. These late FAEEs were significantly higher than the FAEEs in 15 different healthy men who had abstained from ethanol for 4.5 days (p < 0.001 and p = 0.001). FAEEs were associated mainly with lipid-free serum but tended to accumulate in very-low-density lipoprotein in patients with moderate hypertriglyceridemia. In heavy drinkers, the FAEEs were increased after ethanol consumption for at least 44 hr. It rem...Continue Reading
References
Jan 31, 1986·Science·E A Laposata, L G Lange
Sep 25, 1995·Archives of Internal Medicine·B YersinA Pécoud
May 1, 1996·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·O M LeschS Kasper
Jan 26, 1996·Journal of Chromatography. B, Biomedical Applications·T G BernhardtM Laposata
Jun 1, 1997·Alcoholism, Clinical and Experimental Research·D A BirdM Laposata
Jul 1, 1997·Gastroenterology·J WernerA L Warshaw
Sep 2, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Laposata
Sep 27, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Michael LaposataBritt L Soderberg
Jan 1, 2003·Clinical Chemistry·Christine MooreKaren Buchi
Citations
Mar 26, 2013·PloS One·Elhaseen ElaminDaisy Jonkers
Jul 3, 2013·Nutrition Reviews·Elhaseen E ElaminDaisy M Jonkers
Jan 23, 2016·Bioanalysis·David OppolzerEugenia Gallardo
May 30, 2013·Drug Metabolism Reviews·Irene ZelnerGideon Koren
May 18, 2005·Alcoholism, Clinical and Experimental Research·K BoruckiH Schmidt-Gayk
Feb 14, 2007·Alcoholism, Clinical and Experimental Research·K BoruckiC Luley
May 28, 2008·Pharmacotherapy·Julie C KissackAmber Leatherwood Roper
Jan 26, 2007·Alcoholism, Clinical and Experimental Research·John-Paul MorfinThomas Beresford
Mar 1, 2006·The Journal of Laboratory and Clinical Medicine·Clark C KuligGregory T Everson
Jun 16, 2007·Analytical Biochemistry·Lucia PolitiAldo Polettini
Oct 19, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Onni Niemelä
Jun 8, 2017·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Clara Pérez-MañáRafael de la Torre
Feb 4, 2012·Journal of Pharmaceutical and Biomedical Analysis·X JoyaS Pichini