PMID: 15252297Jul 15, 2004Paper

In heavy drinkers fatty acid ethyl esters in the serum are increased for 44 hr after ethanol consumption

Alcoholism, Clinical and Experimental Research
K BoruckiC Luley

Abstract

Fatty acid ethyl esters (FAEEs) have been proposed as a marker of ethanol consumption because they can be detected for up to 24 hr after a moderate intake of ethanol, even though blood ethanol remains increased for only 8 hr. Therefore, this study investigated whether FAEEs can be found during a time period exceeding 24 hr in a group of patients who were hospitalized for ethanol detoxification. A second aim was to study the distribution of FAEEs between lipoproteins during that time. Serum samples of 12 patients with acute ethanol intoxication were assayed for FAEEs. Blood samples were drawn 8.2, 20.2, 32.2, and 44.2 hr after hospitalization. FAEEs were quantified by gas chromatography-mass spectrometry. Ethanol was no longer detectable after 20.2 hr from hospitalization, whereas FAEEs were still found after 32.2 and 44.2 hr. These late FAEEs were significantly higher than the FAEEs in 15 different healthy men who had abstained from ethanol for 4.5 days (p < 0.001 and p = 0.001). FAEEs were associated mainly with lipid-free serum but tended to accumulate in very-low-density lipoprotein in patients with moderate hypertriglyceridemia. In heavy drinkers, the FAEEs were increased after ethanol consumption for at least 44 hr. It rem...Continue Reading

References

May 1, 1996·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·O M LeschS Kasper
Jan 26, 1996·Journal of Chromatography. B, Biomedical Applications·T G BernhardtM Laposata
Jun 1, 1997·Alcoholism, Clinical and Experimental Research·D A BirdM Laposata
Sep 2, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Laposata
Sep 27, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Michael LaposataBritt L Soderberg
Jan 1, 2003·Clinical Chemistry·Christine MooreKaren Buchi

❮ Previous
Next ❯

Citations

Jul 3, 2013·Nutrition Reviews·Elhaseen E ElaminDaisy M Jonkers
Feb 14, 2007·Alcoholism, Clinical and Experimental Research·K BoruckiC Luley
May 28, 2008·Pharmacotherapy·Julie C KissackAmber Leatherwood Roper
Jan 26, 2007·Alcoholism, Clinical and Experimental Research·John-Paul MorfinThomas Beresford
Mar 1, 2006·The Journal of Laboratory and Clinical Medicine·Clark C KuligGregory T Everson
Oct 19, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Onni Niemelä
Jun 8, 2017·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Clara Pérez-MañáRafael de la Torre
Feb 4, 2012·Journal of Pharmaceutical and Biomedical Analysis·X JoyaS Pichini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.