In-hospital risk estimation in children with malaria--early predictors of morbidity and mortality

Journal of Tropical Pediatrics
Andrea Sylvia WinklerErich Schmutzhard

Abstract

Rapid diagnosis and adequate therapy are crucial to prevent development of severe disease and death in children suffering from malaria. A reliable but easy system for disease severity assessment would help to fast track seriously ill children and provide suitable therapies for different patient groups. To examine risk factors and appropriate scoring systems in children suffering from malaria for outcome in terms of morbidity and mortality. A prospective, consecutive study in children admitted to the Muhimbili Medical Centre in Dar es Salaam was conducted to evaluate risk factors and test appropriate scoring systems. The simplified Multi-Organ Dysfunction Score (sMODS), a severity of disease classification consisting mainly of clinical data, was applied. Chosen outcome parameters were morbidity and mortality. Results were compared to those obtained from the World Health Organisation (WHO) classification of severe malaria, the Blantyre Coma Scale (BCS) and selected single clinical parameters. Seventy-five children were recruited into the study. Mean age was 28 months ranging from 6 months to 8 years. 'Severe Malaria', according to WHO criteria was evident in 57 patients (76%). Mean sMODS on admission was 15.6 +/- 2. Seven patient...Continue Reading

Citations

Sep 9, 2011·Memórias do Instituto Oswaldo Cruz·Bruno Bezerril Andrade, Manoel Barral-Netto
Sep 13, 2014·Tropical Medicine & International Health : TM & IH
Jul 28, 2017·PloS One·Pierre MornandUNKNOWN Pediatric Imported Malaria Study Group for the ‘Centre National de Référence du Paludisme’

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