In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19.

Cell Metabolism
Xiao-Jing ZhangHongliang Li


Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk of SARS-CoV-2 viral entry by inducing ACE2 expression. Here, we performed a retrospective study on 13,981 patients with COVID-19 in Hubei Province, China, among which 1,219 received statins. Based on a mixed-effect Cox model after propensity score-matching, we found that the risk for 28-day all-cause mortality was 5.2% and 9.4% in the matched statin and non-statin groups, respectively, with an adjusted hazard ratio of 0.58. The statin use-associated lower risk of mortality was also observed in the Cox time-varying model and marginal structural model analysis. These results give support for the completion of ongoing prospective studies and randomized controlled trials involving statin treatment for COVID-19, which are needed to further validate the utility of this class of drugs to combat the mortality of this pandemic.


Jun 1, 1996·Annals of Internal Medicine·M J Glesby, D R Hoover
May 21, 1998·The New England Journal of Medicine·D A RedelmeierG L Booth
Feb 25, 2006·Nature Reviews. Immunology·Carl Nathan
Apr 1, 2009·The New England Journal of Medicine·Bengt C FellströmUNKNOWN AURORA Study Group
Sep 28, 2010·American Journal of Respiratory and Critical Care Medicine·Thelma R CraigDaniel F McAuley
Jan 17, 2012·American Journal of Respiratory and Critical Care Medicine·Jin-Fu XuUNKNOWN COPDGene Investigators
Jan 26, 2013·American Journal of Respiratory and Critical Care Medicine·Peter KrugerUNKNOWN ANZ-STATInS Investigators–ANZICS Clinical Trials Group
Jul 9, 2013·Antiviral Research·David S Fedson
Aug 3, 2013·BMJ Open·Akbar K WaljeePeter Dr Higgins
Oct 11, 2013·JAMA : the Journal of the American Medical Association·Laurent PapazianUNKNOWN STATIN-VAP Study Group
May 20, 2014·The New England Journal of Medicine·Jonathon D TruwitB Taylor Thompson
Jun 12, 2014·Diabetes·Brandyn D HenriksboJonathan D Schertzer
Oct 1, 2014·The New England Journal of Medicine·Daniel F McAuleyUNKNOWN Irish Critical Care Trials Group
Jun 29, 2017·American Journal of Respiratory and Critical Care Medicine·Elizabeth SapeyDavid R Thickett
Jul 12, 2017·Annals of Internal Medicine·Tyler J VanderWeele, Peng Ding
Feb 22, 2018·JAMA : the Journal of the American Medical Association·Eddy FanArthur S Slutsky
Jun 19, 2018·Epidemiology·Maya B MathurTyler J VanderWeele
Aug 7, 2018·The Lancet. Respiratory Medicine·Carolyn S CalfeeUNKNOWN Irish Critical Care Trials Group
Oct 6, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Denitsa Vasileva, Alaa Badawi
Nov 26, 2018·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B PertzovL Leibovici
Jan 25, 2019·JAMA : the Journal of the American Medical Association·Sebastien HaneuseDavid Arterburn
Jun 18, 2019·American Journal of Respiratory and Critical Care Medicine·Elizabeth SapeyDavid R Thickett
Feb 11, 2020·Intensive Care Medicine·Yaseen M ArabiFrederick G Hayden
Mar 15, 2020·The Lancet. Respiratory Medicine·Lei FangMichael Roth
Apr 2, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Andrew M SouthMark C Chappell
Apr 9, 2020·Pharmacotherapy·Simin Dashti-Khavidaki, Hossein Khalili
Apr 30, 2020·Nature Reviews. Immunology·Matthew Zirui TayLisa F P Ng
Apr 30, 2020·European Heart Journal. Cardiovascular Pharmacotherapy·Vincenzo CastiglioneGiuseppe Vergaro
May 2, 2020·The New England Journal of Medicine·Giuseppe ManciaGiovanni Corrao
May 14, 2020·Archives of Medical Science : AMS·Željko ReinerAmirhossein Sahebkar
Jun 13, 2020·European Heart Journal. Cardiovascular Pharmacotherapy·Maurizio Bifulco, Patrizia Gazzerro

❮ Previous
Next ❯


Aug 19, 2020·Expert Review of Anti-infective Therapy·Paul E MarikG Umberto Meduri
Aug 26, 2020·QJM : Monthly Journal of the Association of Physicians·Dong YangAnlin Peng
Sep 10, 2020·Journal of Medical Virology·Chia Siang Kow, Syed Shahzad Hasan
Sep 4, 2020·European Heart Journal·Peter Libby, Thomas Lüscher
Aug 25, 2020·SN Comprehensive Clinical Medicine·Shifa BangiAmna Qamar
Sep 13, 2020·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Syed Shahzad HasanHamid A Merchant
Oct 8, 2020·World Journal of Virology·Sveva Di FrancoMarco Fiore
Oct 21, 2020·Journal of Cellular Physiology·Mallikarjun PatilPrasanna Krishnamurthy
Oct 17, 2020·Scientific Reports·Wilnard Y T TanRinkoo Dalan
Oct 24, 2020·Journal of the American Heart Association·Omar SaeedUlrich P Jorde
Sep 26, 2020·Clinical and Experimental Pharmacology & Physiology·Zhiguo WangJun-Ping Liu
Nov 10, 2020·Frontiers in Immunology·Chanan MeydanHermona Soreq
Sep 23, 2020·British Journal of Clinical Pharmacology·Jennifer H Martin, Richard Head
Nov 3, 2020·European Heart Journal. Cardiovascular Pharmacotherapy·Lluís MasanaOn Behalf Of The Stacov-Xula Research Group
Dec 16, 2020·Journal of Intensive Care Medicine·Pierre KoryPaul E Marik
Dec 18, 2020·Journal of Medical Virology·Juan Luis Gomez MartiAdam M Brufsky
Jan 4, 2021·Rheumatology International·Sakir AhmedOlena Zimba
Jan 8, 2021·Immunopharmacology and Immunotoxicology·Tarek KashourImad M Tleyjeh
Jan 11, 2021·Briefings in Bioinformatics·Shasha LiChenyang Lu
Oct 24, 2020·Cell Systems·Katherine A OvermyerAriel Jaitovich
Feb 6, 2021·Postgraduate Medical Journal·Rimesh PalSukrita Bhattacharjee
Oct 17, 2020·Radiation Research·Carmen I RiosAndrea L DiCarlo
Feb 18, 2021·Revista Española De Cardiología·Álvaro AparisiJ Alberto San Román
Nov 15, 2020·Nature Reviews. Endocrinology·Soo LimMichael A Nauck
Dec 10, 2020·Immunity & Ageing : I & a·Alistair V W NunnJimmy D Bell
Feb 2, 2021·Translational Medicine Communications·Payam PeymaniSaeid Ghavami
Dec 4, 2020·Journal of Public Health Policy·David S Fedson
Dec 30, 2020·Journal of Molecular and Cellular Cardiology·Walid HamoucheLahouaria Hadri

❮ Previous
Next ❯

Methods Mentioned


Clinical Trials Mentioned


Software Mentioned

R package “ fmsb ”
SPSS Statistics

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.