In human non-REM sleep, more slow-wave activity leads to less blood flow in the prefrontal cortex

Scientific Reports
Laura TüshausPeter Achermann

Abstract

Cerebral blood flow (CBF) is related to integrated neuronal activity of the brain whereas EEG provides a more direct measurement of transient neuronal activity. Therefore, we addressed what happens in the brain during sleep, combining CBF and EEG recordings. The dynamic relationship of CBF with slow-wave activity (SWA; EEG sleep intensity marker) corroborated vigilance state specific (i.e., wake, non-rapid eye movement (NREM) sleep stages N1-N3, wake after sleep) differences of CBF e.g. in the posterior cingulate, basal ganglia, and thalamus, indicating their role in sleep-wake regulation and/or sleep processes. These newly observed dynamic correlations of CBF with SWA - namely a temporal relationship during continuous NREM sleep in individuals - additionally implicate an impact of sleep intensity on the brain's metabolism. Furthermore, we propose that some of the aforementioned brain areas that also have been shown to be affected in disorders of consciousness might therefore contribute to the emergence of consciousness.

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Citations

Oct 17, 2019·Nature Reviews. Neuroscience·Antoine R AdamantidisThomas C Gent
May 31, 2020·The Journal of Comparative Neurology·Robert P Vertes, Stephanie B Linley
Jun 17, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Alessandra CaporaleFelix W Wehrli
Nov 7, 2019·Sleep·Maude BouchardJulie Carrier
Jan 14, 2021·Brain : a Journal of Neurology·Lukas B Krone, Vladyslav V Vyazovskiy

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

CONN
MATLAB
BrainVision Analyzer
SAS
xjView
SPM8

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