In in vivo evaluation of the anti-inflammatory and analgesic activities of compound Muniziqi granule in experimental animal models

BMC Complementary and Alternative Medicine
Juanjuan ChengChanghong Wang

Abstract

Compound Muniziqi granule (MNZQ), a traditional Uighur medicinal preparation, comprises 13 species of medicinal plants. MNZQ is traditionally used for regulating body immunity, modulating inflammation and pain, detoxification, and inhibiting tumor growth. This study aims to scientifically evaluate the anti-inflammatory and analgesic activities of MNZQ, support its clinical use and further research with scientific evidence. The analgesic activity of MNZQ was evaluated using hot plate test and acetic acid-induced abdominal writhing test. Acute inflammation was evaluated using xylene-induced ear edema and carrageenan-induced paw edema models, while chronic inflammation was evaluated using cotton pellet-induced granuloma model. MNZQ exerted analgesic activities with a significant dose-dependent increase in latency in the hot plate test. The percentage inhibition suggested that MNZQ exhibited analgesic activities in the central nervous system. Meanwhile, MNZQ at 0.8, 2.4, and 7.2 g/kg strongly inhibited the acetic acid-induced writhing response by 25.22% (p < 0.01), 44.60% (p < 0.001), and 49.41% (p < 0.001), respectively. MNZQ also exerted analgesic activities in the peripheral nervous system. Moreover, MNZQ was demonstrated a sign...Continue Reading

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Citations

Nov 22, 2017·Archives of Physiology and Biochemistry·Raouia DhouibiHanen Affes
Sep 28, 2017·The American Journal of Chinese Medicine·Yun Hee JeongJin Yeul Ma
Sep 16, 2020·Analytical Methods : Advancing Methods and Applications·Tianming WangYueming Ma
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Dec 16, 2021·Brazilian Journal of Biology = Revista Brasleira De Biologia·Romina ChitsazZahra Mousavi

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