In Ivorian school-age children, infection with hookworm does not reduce dietary iron absorption or systemic iron utilization, whereas afebrile Plasmodium falciparum infection reduces iron absorption by half

The American Journal of Clinical Nutrition
Dominik GlinzRita Wegmüller

Abstract

In sub-Saharan Africa, parasitic diseases and low bioavailable iron intake are major causes of anemia. Anemia results from inflammation, preventing iron recycling and decreasing dietary iron absorption. Hookworm, Plasmodium, and Schistosoma infections contribute to anemia, but their influence on dietary iron absorption and recycling is unknown. The objective was to measure inflammation biomarkers, hepcidin, iron absorption, and utilization pre- and posttreatment in children with afebrile malaria, hookworm, and Schistosoma haematobium infection. Ivorian children aged 11-17 y with afebrile Plasmodium falciparum (n = 17), hookworm (n = 16), or S. haematobium infection (n = 8) consumed a syrup containing 3 mg ⁵⁷Fe as ferrous sulfate and received an intravenous infusion of 50 μg ⁵⁸Fe as ferrous citrate. Children were treated for their respective infection, and the iron studies were repeated 4 wk later. Iron and inflammation biomarkers and hepcidin were measured. Geometric mean iron absorptions in the afebrile malaria and hookworm groups were 12.9% and 32.2% (P < 0.001) before treatment and 23.6% and 30.0% (P = 0.113) after treatment, respectively. Treatment of afebrile malaria reduced inflammation (P < 0.001) and serum hepcidin (P =...Continue Reading

References

Jul 1, 1989·Clinical Microbiology Reviews·D L Boros
Mar 1, 1985·The American Journal of Tropical Medicine and Hygiene·L S StephensonM L Oduori
Mar 1, 1994·The British Journal of Nutrition·P KastenmayerR F Hurrell
Oct 1, 1996·The American Journal of Tropical Medicine and Hygiene·R J StoltzfusR Yip
Sep 18, 2003·The British Journal of Nutrition·Jack R DaintySusan J Fairweather-Tait
Mar 2, 2005·Best Practice & Research. Clinical Haematology·Tomas Ganz
Apr 9, 2005·The American Journal of Clinical Nutrition·Mark A RoeSusan J Fairweather-Tait
Jun 22, 2005·Trends in Parasitology·Jennifer F FriedmanStephen T McGarvey
Nov 2, 2005·International Journal for Parasitology·Giovanna RasoJürg Utzinger
Nov 13, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·Richard NdyomugyenyiPascal Magnussen
May 8, 2008·PloS One·Conor P DohertyAndrew M Prentice
Jan 13, 2009·Clinical Microbiology Reviews·Denise L DoolanJ Kevin Baird
Nov 18, 2009·The Journal of Parasitology·Dominik GlinzEliézer K N'Goran
May 27, 2010·Tropical Medicine & International Health : TM & IH·Jennifer L Smith, Simon Brooker
Aug 27, 2010·Clinical Chemistry·Joyce J C KrootDorine W Swinkels
Dec 18, 2010·Journal of Korean Medical Science·Hee Jae HyunSung-Tae Hong
Feb 2, 2011·Tropical Medicine & International Health : TM & IH·Theresa W GyorkosMartín Casapía
Feb 25, 2011·Blood·Tomas Ganz
Jul 2, 2011·Nature·Bassirou BonfohMarcel Tanner
May 11, 2012·Malaria Journal·Giovanna RasoPenelope Vounatsou
Jun 30, 2012·The Journal of Allergy and Clinical Immunology·Mark S PearsonJeffrey Bethony
Aug 1, 2012·The American Journal of Tropical Medicine and Hygiene·Aurélie A RighettiJürg Utzinger
Sep 18, 2012·Microbes and Infection·R Alan Wilson
Dec 4, 2013·Blood·Nicholas J KassebaumChristopher J L Murray
Apr 5, 2014·Lancet·Daniel G ColleyCharles H King
Jul 13, 2014·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Donna J Chapman

❮ Previous
Next ❯

Citations

Dec 15, 2015·FEMS Microbiology Reviews·Katrien DeroostPhilippe E Van den Steen
Dec 3, 2015·EBioMedicine·Sarah H AtkinsonThomas N Williams
Dec 16, 2016·Nutrition Reviews·Andrew M PrenticeJörg Spieldenner
Apr 12, 2017·British Journal of Haematology·Femkje A M JonkerMichael Boele van Hensbroek
Aug 31, 2016·The American Journal of Tropical Medicine and Hygiene·Khov KuongFrank T Wieringa
Sep 2, 2015·The American Journal of Tropical Medicine and Hygiene·Alicia Chang CojulunCharles H King
Oct 3, 2018·Pharmaceuticals·John Muthii Muriuki, Sarah H Atkinson
Feb 28, 2016·The Cochrane Database of Systematic Reviews·Ami NeubergerMical Paul
Mar 11, 2016·PloS One·Silvana Gomes BenzecryHeitor Pons Leite
Sep 5, 2020·Public Health Nutrition·Julie JessonUNKNOWN TALENT collaboration
Jun 8, 2018·The Journal of Nutrition·Sean LynchDaniel J Raiten
Mar 17, 2018·The Journal of Nutrition·Ajibola I AbioyeJennifer F Friedman
Feb 24, 2021·Nature Medicine·John Muthii MuriukiSarah H Atkinson
Apr 9, 2021·The American Journal of Clinical Nutrition·Wanhui KangKimberly O O'Brien
Sep 21, 2020·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A Lemoine, P Tounian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.