In-line quantification of drug and excipients in cohesive powder blends by near infrared spectroscopy

International Journal of Pharmaceutics
C V LiewP W S Heng

Abstract

This work was aimed at investigating the utility of near infrared (NIR) spectroscopy for simultaneous in-line quantification of drug and excipients in cohesive powder blends in a bin blender. A model formulation containing micronized chlorpheniramine maleate (microCPM), lactose, microcrystalline cellulose (MCC) and magnesium stearate (MgSt) was selected for the blending study. An optical head comprising a sapphire window mounted on the lid of the bin was used to collect in-line NIR spectral data of the powder blends. Validated partial least square (PLS) calibration models were used to quantify each component from the NIR spectra of the blends. Additionally, effects of premixing by sieving and high shear mixing and use of an internal prism fixed within the bin on the mixing performance of each component were studied. The statistical results obtained for PLS calibration models and their validation showed the sensitivity of NIR for accurate quantification of blend components. The blend prepared with high shear premixing and with prism achieved uniformity more rapidly than that with high shear premixing but without prism during blending in a bin blender. Premixing using sieving proved to be inadequate for uniform mixing of the blen...Continue Reading

Citations

Apr 8, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Patrick R WahlJohannes G Khinast
Dec 3, 2014·Journal of Pharmaceutical and Biomedical Analysis·Slobodan ŠašićHugh Clarke
Apr 19, 2013·Drug Development and Industrial Pharmacy·Ioan TomutaLoredana Vonica
Mar 21, 2013·Journal of Pharmaceutical and Biomedical Analysis·Howard W WardHugh Clarke
Apr 4, 2012·Journal of Pharmaceutical and Biomedical Analysis·Marzena Jamrógiewicz
May 18, 2010·International Journal of Pharmaceutics·A D KarandeP W S Heng
May 20, 2014·International Journal of Pharmaceutics·Hiroshi NakagawaNaoki Wakiyama
Jan 1, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jean-Maxime GuayNicolas Abatzoglou
Nov 24, 2012·International Journal of Pharmaceutics·Hiroshi NakagawaNaoki Wakiyama
Aug 21, 2016·International Journal of Pharmaceutics·Andrés D Román-OspinoRodolfo J Romañach
Oct 19, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amit AlexanderShailendra Saraf
Oct 25, 2013·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Ioan TomuţăSorin E Leucuţa
Jun 26, 2018·Pharmaceutical Development and Technology·Pedro DurãoRyan Gosselin
Jan 24, 2019·AAPS PharmSciTech·Allison Crouter, Lauren Briens
Oct 17, 2018·Pharmaceutics·Ramon CabiscolArno Kwade
Apr 25, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Zhonghui HuangRajesh N Davé
Aug 8, 2020·International Journal of Pharmaceutics·Nobel O Sierra-VegaRafael Méndez

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