In mice repeated administration of electroconvulsive shock or desmethylimipramine produces rapid alterations in 5-HT2-mediated head-twitch responses and cortical 5-HT2 receptor number

European Journal of Pharmacology
A Metz, D J Heal

Abstract

Mice treated with a single electroconvulsive shock (ECS) daily for up to 3 days showed progressively enhanced head-twitch to 5-methoxy-N,N'-dimethyltryptamine 24 h after 1,2 and 3 shocks. Injection of desmethylimipramine (DMI, 5 mg/kg) twice daily for up to 3.5 days progressively decreased head-twitch responses on days 2, 3 and 4. Cortical [3H]ketanserin binding was increased by ECS X 3 and decreased by 3.5 days DMI treatment. These data demonstrate that in mice antidepressant treatments produce rapid changes 5-HT2 function.

Citations

Feb 23, 2011·Psychopharmacology·John P Dougherty, Vincent J Aloyo
Mar 26, 2003·Life Sciences·Dirk Van OekelenJosée E Leysen
Oct 25, 2011·Development and Psychopathology·Theodore P BeauchaineNatalia Potapova
Nov 6, 2007·Biochemical Pharmacology·William E FantegrossiChad J Reissig
Jan 1, 1991·Molecular Microbiology·J A Garcia-HorsmanJ E Escamilla

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