In mononeuropathic rats, the enhancement of morphine antinociception by L-365,260, a selective CCK(B) receptor antagonist, depends on the dose of systemic morphine and stimulus characteristics

European Journal of Pharmacology
J J Idänpään-HeikkiläV Kayser

Abstract

The ability of the selective cholecystokinin(B) (CCK(B)) receptor antagonist L-365,260 (0.2 mg/kg s.c.) to modulate the antinociceptive action of relatively low doses of systemic morphine (0.1, 0.3 and 1.0 mg/kg i.v.) was evaluated using a well established rat model of peripheral unilateral mononeuropathy. Behavioural tests based on both mechanical (vocalization threshold to paw pressure) and thermal (struggle latency after immersion of the paw into a cold (10 degrees C), warm (44 degrees C) or hot (46 degrees C) water bath) stimuli were used. Experiments were performed 2 weeks after the surgery when the pain-related behaviour has fully developed. We demonstrated a differential effect of L-365,260 depending both on the dose of morphine and the test used. Pretreatment with the CCK(B) receptor antagonist (0.2 mg/kg) inverted the ineffectiveness of the lowest dose (0.1 mg/kg i.v.) of morphine against the noxious (46 degrees C) thermal stimulus, and the effect of the combination was equal to that seen after the dose 0.3 mg/kg of morphine alone. Likewise, in the mechanical test, the already enhanced effect of this dose (0.1 mg/kg) of morphine on the nerve-injured paw was further increased (by 4-fold) after L-365,260 pretreatment. Th...Continue Reading

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S A WankT Slattery
Apr 25, 1992·Proceedings of the National Academy of Sciences of the United States of America·A S KopinM Beinborn
Jan 1, 1986·Brain Research·T H MoranP R McHugh
Jul 26, 1988·European Journal of Pharmacology·M RattrayJ De Belleroche
Jun 4, 1982·European Journal of Pharmacology·S ItohY Maeda
Apr 22, 1982·Brain Research·M C Beinfeld, M Palkovits
Mar 1, 1994·Trends in Pharmacological Sciences·L StanfaZ Wiesenfeld-Hallin

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Citations

May 30, 2002·Progress in Neurobiology·Mark J Millan
Feb 13, 1999·Progress in Neurobiology·M J Millan
Jun 15, 1999·Progress in Neurobiology·F Noble, B P Roques
Jan 12, 2001·Journal of Neurophysiology·M M HeinricherV Tortorici

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