Abstract
1. Chick embryos were orally immunised at day 16 of incubation by injection of heat-killed Campylobacter jejuni organisms into the amniotic fluid. The response to vaccination was observed at 5 d after hatching or, in some birds which received a postnatal oral booster vaccination, at 7 d after hatching, and the response was observed at 14 d of age. 2. The titres of antibody in serum, bile and intestinal scrapings, the distribution of immunoglobulin-containing cells in the spleen, duodenum and ileum and the expression on peripheral blood leukocytes (PBL) of the T cell surface markers CD3, CD4 and CD8 were determined. 3. Whereas low titres of anti-flagellin antibody were detected in serum, bile and intestinal scrapings of unimmunised birds, high titres were observed in immunised birds. 4. An increase in antibody of all isotypes was detectable in serum but the elevation in IgA antibody in intestinal scrapings and bile was particularly striking. This response was reflected in a dramatic increase in immunoglobulin-containing cells, detected by fluorescent histology, particularly those associated with IgA and IgM isotypes in the spleen and intestine of immunised birds. 5. Secondary oral boosting after hatching resulted in a depression...Continue Reading
References
Jul 1, 1979·Infection and Immunity·T T BrownS I Bistner
Nov 1, 1978·The Journal of Experimental Medicine·A J Husband, J L Gowans
Dec 1, 1991·FEMS Microbiology Immunology·J Holmgren
Jun 1, 1987·Infection and Immunity·E McSweeganR I Walker
Sep 1, 1987·American Journal of Public Health·R V TauxeN Hargrett-Bean
Apr 1, 1986·American Journal of Public Health·N V HarrisC M Nolan
Apr 1, 1972·Infection and Immunity·M Richardson, G H Conner
Oct 1, 1982·The Journal of Hygiene·M B Skirrow
Jun 1, 1980·The Australian Journal of Experimental Biology and Medical Science·A J Husband
Mar 1, 1994·Infection and Immunity·C K LeeT P Monath
Nov 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·R ASOFSKYG J THORBECKE
Citations
Mar 16, 2000·Developmental and Comparative Immunology·W I MuirA J Husband
Dec 31, 1997·Vaccine·B E RiceS W Joseph
Sep 1, 1996·British Poultry Science·P R WiddersK A Long
Aug 7, 2003·Applied and Environmental Microbiology·D G Newell, C Fearnley
Jul 3, 2004·The Veterinary Quarterly·T NegashE Gruys
Nov 28, 2012·Expert Review of Vaccines·Ana B GarciaHåkan Vigre
Feb 26, 2015·Human Vaccines & Immunotherapeutics·Miguel O'RyanDavid Montero
Dec 5, 2014·Epidemiology and Infection·S BahrndorffB Hald
Jun 1, 2016·Frontiers in Microbiology·Patrycja A KobiereckaElżbieta K Jagusztyn-Krynicka
Apr 13, 2011·Veterinary Microbiology·David HermansFrank Pasmans
Nov 28, 2017·PloS One·Marine MeunierMarianne Chemaly
Jul 3, 2019·Poultry Science·Jasmien VandeputteAn Garmyn
Oct 21, 2016·PloS One·Katarzyna A RadomskaJos P M van Putten
Jan 25, 2011·Microbial Biotechnology·Byeonghwa JeonQijing Zhang
Nov 7, 2015·Journal of Applied Microbiology·M MeunierM Chemaly
Apr 9, 2020·Avian Diseases·Julia K SchmiedekeUlrike Blohm
May 22, 2020·Bulletin of the National Research Centre·Nagwa S Rabie, Zeinab M S Amin Girh
Nov 17, 2020·Frontiers in Veterinary Science·Graham A J RedweikMelha Mellata
Oct 21, 2017·Poultry Science·K E C ElliottE D Peebles
Jul 23, 2013·Poultry Science·T AnnamalaiG Rajashekara
Jan 17, 2007·Vaccine·Marcel R de ZoeteJaap A Wagenaar