In-parallel comparative evaluation between multiparametric magnetic resonance imaging, prostate cancer antigen 3 and the prostate health index in predicting pathologically confirmed significant prostate cancer in men eligible for active surveillance

BJU International
Francesco PorpigliaRocco Damiano

Abstract

To assess the performance capabilities of multiparametric magnetic resonance imaging (mpMRI), the prostate health index (PHI) and prostate cancer antigen 3 (PCA3) in predicting the presence of pathologically confirmed significant prostate cancer (PCSPCa), according to the European Randomized Study of Screening Prostate Cancer definition, in a single cohort of patients who underwent radical prostatectomy (RP) but who were eligible for active surveillance (AS). An observational retrospective study was performed in 120 patients with prostate cancer (PCa), treated with robot-assisted RP but eligible for AS according to Prostate Cancer Research International: Active Surveillance criteria. Blood and urine specimens were collected before initial prostate biopsy for PHI and PCA3 measurements, respectively. In addition, all patients underwent mpMRI, preoperatively and 6-8 weeks after biopsy, with a 1.5T scanner using a four-to-five-channel phase array coil combined with an endorectal coin. mpMRI images were assessed and diagrams showing the prostate sextants were used to designate regions of abnormality within the prostate. Prostate findings were assigned to one of five categories according to Prostate Imaging-Reporting and Data System ...Continue Reading

References

Sep 26, 2003·The American Journal of Surgical Pathology·Michael E ChenPatricia Troncoso
Aug 13, 2005·The American Journal of Surgical Pathology·Jonathan I EpsteinUNKNOWN ISUP Grading Committee
Nov 14, 2006·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Andrew J Vickers, Elena B Elkin
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laurence KlotzAndrew Loblaw
Sep 8, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Theo H van der KwastUNKNOWN ISUP Prostate Cancer Group
Dec 1, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew R CooperbergPeter R Carroll
Feb 11, 2012·European Radiology·Jelle O BarentszUNKNOWN European Society of Urogenital Radiology
Jun 16, 2012·European Urology·Marc A Dall'EraMark S Soloway
Nov 20, 2012·European Urology·Meelan BulMonique J Roobol
Jan 19, 2013·Investigative Radiology·Diederik M SomfordUNKNOWN MR-PRIAS Collaboration Group
Mar 12, 2013·European Urology·Elizabeth D SelvaduraiChris C Parker
Nov 12, 2013·European Urology·Maria C Mir, Andrew J Stephenson
Dec 17, 2014·European Urology·Ivo G SchootsCaroline M Moore
Dec 17, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laurence KlotzAndrew Loblaw
Dec 20, 2014·BioMed Research International·Linda M JohnsonBaris Turkbey

❮ Previous
Next ❯

Citations

Jul 15, 2015·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Giorgio Ivan RussoGiuseppe Morgia
Jun 2, 2015·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Giorgio I RussoGiuseppe Morgia
Jun 10, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Francesco PorpigliaFilippo Russo
Oct 30, 2016·International Journal of Molecular Sciences·Xavier Filella, Laura Foj
May 31, 2017·International Journal of Molecular Sciences·Matteo FerroDaniela Terracciano
Feb 18, 2017·Current Opinion in Urology·Hasan Dani, Stacy Loeb
Jul 19, 2018·Expert Review of Anticancer Therapy·Guillaume Ploussard, Alexandre de la Taille
Nov 26, 2019·Oncotarget·Ana Emília Goulart LemosEtel Rodrigues Pereira Gimba
Nov 23, 2017·Frontiers in Oncology·Zachary A GlaserSoroush Rais-Bahrami
Jul 8, 2018·World Journal of Urology·Romain MathieuSébastien Vincendeau
Nov 7, 2017·The Urologic Clinics of North America·Stacy Loeb, Hasan Dani
Jul 3, 2021·International Journal of Molecular Sciences·Belén Pastor-NavarroJosé Antonio López-Guerrero

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.