PMID: 7544368May 1, 1995Paper

In patients with orthotopic liver transplantation, serum markers of cholestasis are unreliable indicators of biliary secretion

Journal of Hepatology
P SauerL Theilmann

Abstract

In patients after orthotopic liver transplantation, treatment with the novel immunosuppressant FK 506 may lead to elevated levels of alkaline phosphatase, gamma glutamyl transferase and bilirubin. Up to now it was unclear whether the excretory capacity of the liver in such patients is impaired. We measured quantitatively the secretion of bile acids, phospholipids and cholesterol using the duodenal perfusion method, which allows assessment of biliary secretion without interruption of the enterohepatic circulation. Six healthy volunteers served as controls. All patients studied after orthotopic liver transplantation had elevated concentrations of serum alkaline phosphatase and gamma glutamyl transferase, whereas only half of them had slightly abnormal serum bilirubin levels. On average, the FK 506-treated patients excreted 1.23 +/- 0.27 mmol/h bile acids, 0.23 +/- 0.04 mmol/h phospholipids and 0.11 +/- 0.02 mmol/h cholesterol, which was not significantly different from the healthy controls. The normal secretion rates of biliary bile acids and lipids in FK 506-treated patients with elevated serum alkaline phosphatase and gamma glutamyl transferase indicate that the excretory capacity of the transplanted liver has completely recove...Continue Reading

References

Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B G EriczonB Angelin
Aug 18, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·A StiehlS Walker
Jan 1, 1960·Methods of Biochemical Analysis·P TALALAY
Jan 1, 1960·Acta Endocrinologica. Supplementum·P TALALAY, H G WILLIAMS-ASHMAN

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Citations

Feb 20, 2003·Transplantation Proceedings·K MizutaH Kawarasaki
Jun 13, 1998·Transplantation·H Vilca MelendezN Heaton
Jun 25, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·H Vilca MelendezN D Heaton
Nov 7, 1999·Transplant International : Official Journal of the European Society for Organ Transplantation·K MizutaK Hashizume
Apr 25, 2012·Journal of Transplantation·Raffaele Cursio, Jean Gugenheim
Apr 21, 2006·Transplant International : Official Journal of the European Society for Organ Transplantation·Leonardo BaiocchiGiuseppe Tisone

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