In pediatric familial hypercholesterolemia, lipoprotein(a) is more predictive than LDL-C for early onset of cardiovascular disease in family members

Journal of Clinical Lipidology
Amy W ZawackiAmy L Peterson

Abstract

Low-density lipoprotein cholesterol (LDL-C) level and lipoprotein(a) [Lp(a)] ≥ 50 mg/dL predict atherosclerotic cardiovascular disease (ASCVD) risk in adults with familial hypercholesterolemia (FH), but their role for children with FH is less clear. This study examined the relationship between elevated Lp(a) and LDL-C levels in a pediatric population with FH and onset of ASCVD in family members. Retrospective review of pediatric patients with FH identified LDL-C, Lp(a), and family history of ASCVD. Logistic regression modeling evaluated the association between the child's Lp(a) and peak LDL-C level with earliest age of ASCVD onset in their family. One hundred twenty-nine children from 109 families were identified. Children from families with early-onset ASCVD were 3 times more likely to have high Lp(a) than those with a family history of late-onset ASCVD (OR: 3.77, 95% CI: 1.16-12.25, P = .027) but were not more likely to have highly elevated peak LDL-C (≥190 mg/dL) (OR: 0.45, 95% CI: 0.11-1.80, P = .26). Children with FH and family history of early-onset ASCVD were more likely to have Lp(a) ≥50 mg/dL than children with FH and family history of late-onset ASCVD. Family history of early-onset ASCVD was more predictive of a child...Continue Reading

Citations

Apr 19, 2020·Current Opinion in Lipidology·Anne Langsted, Børge G Nordestgaard
Dec 1, 2019·Journal of Clinical Medicine·Natalie C WardGerald F Watts
Jul 17, 2019·Clinical Therapeutics·Heitor O SantosRodrigo C O Macedo
Aug 22, 2020·The Journal of Pediatrics·Brenda KohnDon P Wilson
Jan 5, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Elizabeth YeungSonali S Patel
Mar 25, 2020·Trends in Cardiovascular Medicine·Vanessa BianconiUNKNOWN International Lipid Expert Panel (ILEP)
Jun 21, 2021·Current Atherosclerosis Reports·Anne Langsted, Børge G Nordestgaard
Aug 29, 2021·Current Atherosclerosis Reports·Amy L PetersonDon P Wilson
Jan 14, 2022·Journal of Atherosclerosis and Thrombosis·Yu KataokaMariko Harada-Shiba
Feb 3, 2022·Current Atherosclerosis Reports·Anne Langsted, Børge G Nordestgaard

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