In previously immunized elderly adults inactivated influenza A (H1N1) virus vaccines induce poor antibody responses that are not enhanced by liposome adjuvant

Vaccine
D C PowersP J Pietrobon

Abstract

In a randomized, double-blinded study, 77 healthy elderly seropositive volunteers (95% of whom had received influenza vaccine within the prior 5 years) were immunized with either monovalent liposome-adjuvanted or control subvirion vaccine containing inactivated influenza A/Taiwan/1/86 (H1N1) virus. The experimental vaccine was well-tolerated but elicited serologic responses that were no different in frequency or magnitude from those induced by the control vaccine. Less than 20% of subjects in either group mounted a fourfold or greater rise in antibody titer. Sixty-three elderly subjects who had participated in the liposome vaccine trial were reimmunized 18 weeks later with licensed trivalent subvirion vaccine, and their serologic responses were compared with those of 26 young adults. Significant rises in hemagglutination inhibition (HAI) antibody titers to the A/Texas/36/91 (H1N1), A/Beijing/32/92 (H3N2) and B/Panama/45/90 components occurred in 10%, 76% and 56% of elderly vaccinees, respectively, compared to 92% (p < 0.0001), 100% (p < 0.005) and 88% (p < 0.005) of young vaccines, respectively. Age differences in seroresponse rates to the H1N1 subtype antigen were significant even when comparing young and old adults with ident...Continue Reading

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Sep 1, 1996·Clinical and Diagnostic Laboratory Immunology·D C PowersB E Johansson

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