In rats breathing from a nonrebreathing system, substitution of desflurane for isoflurane toward the end of anesthesia incompletely restores the time of recovery toward that of desflurane

Anesthesia and Analgesia
D H GongE I Eger

Abstract

The lower solubility of desflurane allows a more rapid emergence from anesthesia than after anesthesia with the more soluble but less expensive anesthetic, isoflurane. Some practitioners use isoflurane for maintenance of anesthesia, crossing over to desflurane later in maintenance in an attempt to combine the cost-effectiveness of isoflurane with the rapid emergence from desflurane. We hypothesized that this maneuver would not accomplish its goals. Twenty-four male Sprague-Dawley rats received 1.2 minimum alveolar anesthetic concentration (MAC) of desflurane for the final 15, 30, or 60 min of a 2-h, 1.2-MAC isoflurane anesthetic in a nonrebreathing anesthesia system. We measured the time from cessation of anesthetic administration to the time each rat righted himself twice. Immediately after righting for the second time, we tested each rat's ability to remain atop a rotating rod (Rota-Rod) for 60 s continuously. Early (righting reflex) and late (Rota-Rod) recovery occurred more rapidly (P < 0.001) after 120 min of anesthesia with desflurane alone than after 120 min of anesthesia with isoflurane alone. A cross-over period of 30 min or longer produced a righting reflex time that did not differ from that found with desflurane alon...Continue Reading

References

Mar 1, 1991·Anesthesiology·N YasudaA Fassoulaki
Oct 1, 1971·Anesthesiology·T H CromwellW M Dolan
Dec 1, 1993·Anesthesiology·R B Weiskopf, E I Eger

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Citations

May 23, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H Vaghadia
Oct 22, 2015·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ikuomi MikuniHiroshi Iwasaki
Jul 28, 2017·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Taina B StrikeDavid M Neilson

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