In Search of a Cure for Sepsis: Taming the Monster in Critical Care Medicine

Journal of Innate Immunity
Emeka B Okeke, Jude E Uzonna

Abstract

In spite of over half a century of research, sepsis still constitutes a major problem in health care delivery. Although advances in research have significantly increased our knowledge of the pathogenesis of sepsis and resulted in better prognosis and improved survival outcome, sepsis still remains a major challenge in modern medicine with an increase in occurrence predicted and a huge socioeconomic burden. It is generally accepted that sepsis is due to an initial hyperinflammatory response. However, numerous efforts aimed at targeting the proinflammatory cytokine network have been largely unsuccessful and the search for novel potential therapeutic targets continues. Recent studies provide compelling evidence that dysregulated anti-inflammatory responses may also contribute to sepsis mortality. Our previous studies on the role of regulatory T cells and phosphoinositide 3-kinases in sepsis highlight immunological approaches that could be explored for sepsis therapy. In this article, we review the current and emerging concepts in sepsis, highlight novel potential therapeutic targets and immunological approaches for sepsis treatment and propose a biphasic treatment approach for management of the condition.

Citations

Jul 1, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emeka B OkekeJude E Uzonna
Jun 1, 2018·Journal of Innate Immunity
Nov 30, 2016·Antimicrobial Agents and Chemotherapy·Mario Martínez-FlorensaFrancisco Lozano
Jul 10, 2019·Frontiers in Cell and Developmental Biology·Christina NedevaHamsa Puthalakath
Oct 26, 2018·Journal of Innate Immunity·Arne Egesten, Heiko Herwald

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