In search of a germ theory equivalent for chronic disease.

Preventing Chronic Disease
Garry Egger

Abstract

The fight against infectious disease advanced dramatically with the consolidation of the germ theory in the 19th century. This focus on a predominant cause of infections (ie, microbial pathogens) ultimately led to medical and public health advances (eg, immunization, pasteurization, antibiotics). However, the resulting declines in infections in the 20th century were matched by a rise in chronic, noncommunicable diseases, for which there is no single underlying etiology. The discovery of a form of low-grade systemic and chronic inflammation ("metaflammation"), linked to inducers (broadly termed "anthropogens") associated with modern man-made environments and lifestyles, suggests an underlying basis for chronic disease that could provide a 21st-century equivalent of the germ theory.

References

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Citations

May 8, 2014·BioMed Research International·Garry Egger, John Dixon
Feb 6, 2016·Research in Social & Administrative Pharmacy : RSAP·Pey Wen Mak, Judith Singleton
Jul 21, 2015·Cell Metabolism·Ana Paula Arruda, Gökhan S Hotamisligil
Jun 1, 2016·Medical Hypotheses·L Pruimboom, D Reheis
Oct 1, 2016·International Journal of Environmental Research and Public Health·Kelvin L WallsJohn W D Boddy
Oct 25, 2016·Lancet·Julio Frenk, Octavio Gómez-Dantés
Apr 13, 2017·The Journal of Endocrinology·Rachel BotchlettChaodong Wu
Mar 30, 2017·Journal of Basic and Clinical Physiology and Pharmacology·Oluwafemi Gabriel OluwoleSolomon Umukoro
Jan 13, 2018·Journal of Cellular Physiology·Peramaiyan RajendranChih-Yang Huang
Mar 28, 2019·Current Medicinal Chemistry·Ennio AvolioAntonino De Lorenzo
May 29, 2021·Frontiers in Medicine·Daniel de la SernaLeo Pruimboom

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