In Search of a Gold Standard Patient-Reported Outcome Measure for Use in Chemotherapy- Induced Peripheral Neuropathy Clinical Trials

Cancer Control : Journal of the Moffitt Cancer Center
Ellen M Lavoie SmithCelia M Bridges

Abstract

To test a reduced version-CIPN15-of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Chemotherapy-Induced Peripheral Neuropathy scale (QLQ-CIPN20) to establish a possible gold-standard patient-reported outcome measure for chemotherapy-induced peripheral neuropathy (CIPN). Using a prospective, longitudinal, case-control design, patients (n = 121) receiving neurotoxic chemotherapy completed the CIPN15 at baseline and 12 weeks and underwent objective neurological assessment using the 5-item Total Neuropathy Score-Clinical (TNSc). Healthy controls (n = 30) completed the CIPN15 once. Structural validity was evaluated using factor analysis. Because a stable factor structure was not found, a sum score was used to evaluate measures of the CIPN15's psychometric properties-reliability, validity, sensitivity, and responsiveness-as follows: internal consistency via Cronbach's α and item-item correlations; test-retest reliability via correlation between 2 CIPN15 scores from each patient; concurrent validity via correlation between CIPN15 and 5-item TNSc scores; contrasting group validity via comparison of CIPN15 scores from patients and healthy controls; sensitivity via descriptive statist...Continue Reading

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Jan 12, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Hannah C TimminsSusanna B Park
Apr 12, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Fiona YeoAlexandre Chan
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Feb 2, 2021·The Oncologist·Hannah C TimminsSusanna B Park
Oct 17, 2021·Oncology and Therapy·Jamie BurgessUazman Alam

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