In search of the 'bio-active conformation'--is it induced by the target cell membrane?

Journal of Molecular Recognition : JMR
R Schwyzer

Abstract

Conformations of regulatory peptides interacting with artificial lipid membranes were compared with those of chemically constrained molecules that react selectively with different receptor classes. Striking similarities in the topochemistry of molecules with similar activity were observed. The membrane-induced topomers were almost congruent with the artificial topomers that are selectively recognized by the same receptors. Finally, the ideas developed in the membrane compartments theory which allow a quantitative prediction of receptor preference are compatible with our present knowledge of receptor structure.

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Citations

Mar 26, 2009·European Biophysics Journal : EBJ·Lars ThomasOlaf Zschörnig
Aug 28, 2009·The Journal of Biological Chemistry·Yoshitaka UmetsuKeiichi Kawano
Nov 7, 2014·Journal of Molecular Modeling·Elke HaenseleTimothy Clark
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Jul 23, 2005·Chembiochem : a European Journal of Chemical Biology·Reto Bader, Oliver Zerbe
Nov 23, 2006·Journal of Receptor and Signal Transduction Research·Oliver ZerbeChao Zou
Oct 10, 2007·Journal of Peptide Science : an Official Publication of the European Peptide Society·Sylwia Rodziewicz-MotowidłoCezary Czaplewski
Oct 1, 2009·Chembiochem : a European Journal of Chemical Biology·Tino ZdobinskyHeru Chen
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Aug 7, 2012·Journal of Peptide Science : an Official Publication of the European Peptide Society·Søren L PedersenKnud J Jensen
Sep 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fred Naider, Jeffrey M Becker
May 8, 2018·RSC Advances·Jacopo MarinoOliver Zerbe
Oct 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anette Kaiser, Irene Coin
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Jan 7, 2005·Journal of Medicinal Chemistry·Elodie Archer-LahlouDaniel Fourmy
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Feb 15, 2001·Journal of Medicinal Chemistry·P RoveroD F Mierke
Dec 21, 2006·Biochemistry·Jesper LindLena Mäler
Aug 3, 2021·Molecular Pharmacology·Christopher T SzlenkSenthil Natesan

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